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MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli

Title
MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli
Authors
Im, Seung YeongJeong, JinjuJin, GwonhyuYeom, JiwooJekal, JanghwanLee, Sang-imCho, Jung AhLee, SukkyooLee, YoungmiKim, Dae-HwanBae, MijeongHeo, JinhwaMoon, CheilLee, Chang-Hun
DGIST Authors
Lee, Sang-imLee, SukkyooMoon, CheilLee, Chang-Hun
Issue Date
2019-02
Citation
Scientific Reports, 9
Type
Article
Article Type
Article
Keyword
MONOAMINE-OXIDASE-A; HUMAN SEROTONIN TRANSPORTER; HEART-RATE REACTIVITY; ANTISOCIAL-BEHAVIOR; FUNCTIONAL POLYMORPHISM; CHILDHOOD MALTREATMENT; GENE PROMOTER; POINT MUTATION; BRAIN ACTIVITY; GENOTYPE
ISSN
2045-2322
Abstract
Among the genetic variations in the monoamine oxidase A (MAOA) gene, upstream variable number tandem repeats (uVNTRs) of the promoter have been associated with individual differences in human physiology and aggressive behaviour. However, the evidence for a molecular or neural link between MAOA uVNTRs and aggression remains ambiguous. Additionally, the use of inconsistent promoter constructs in previous studies has added to the confusion. Therefore, it is necessary to demonstrate the genetic function of MAOA uVNTR and its effects on multiple aspects of aggression. Here, we identified three MAOA alleles in Koreans: the predominant 3.5R and 4.5R alleles, as well as the rare 2.5R allele. There was a minor difference in transcriptional efficiency between the 3.5R and 4.5R alleles, with the greatest value for the 2.5R allele, in contrast to existing research. Psychological indices of aggression did not differ among MAOA genotypes. However, our electroencephalogram and electrocardiogram results obtained under aggression-related stimulation revealed oscillatory changes as novel phenotypes that vary with the MAOA genotype. In particular, we observed prominent changes in frontal γ power and heart rate in 4.5R carriers of men. Our findings provide genetic insights into MAOA function and offer a neurobiological basis for various socio-emotional mechanisms in healthy individuals. © 2019, The Author(s).
URI
http://hdl.handle.net/20.500.11750/9634
DOI
10.1038/s41598-019-39103-7
Publisher
Nature Publishing Group
Related Researcher
  • Author Moon, Cheil Moon Lab
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
School of Undergraduate Studies1. Journal Articles
Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles


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