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Temporal changes in cell division rate and genotoxic stress tolerance in quiescent center cells of Arabidopsis primary root apical meristem

Title
Temporal changes in cell division rate and genotoxic stress tolerance in quiescent center cells of Arabidopsis primary root apical meristem
Authors
Timilsina, RupakKim, Jin HeeNam, Hong GilWoo, Hye Ryun
DGIST Authors
Nam, Hong GilWoo, Hye Ryun
Issue Date
2019-03
Citation
Scientific Reports, 9
Type
Article
Article Type
Article
Keyword
DNA-DAMAGE; AUXIN TRANSPORT; MAINTENANCE; GROWTH; IDENTIFICATION; ORGANIZATION; SEGREGATION; EXPRESSION; PROTEINS; BINDING
ISSN
2045-2322
Abstract
Plant roots provide structural support and absorb nutrients and water; therefore, their proper development and function are critical for plant survival. Extensive studies on the early stage of ontogenesis of the primary root have revealed that the root apical meristem (RAM) undergoes dynamic structural and organizational changes during early germination. Quiescent center (QC) cells, a group of slowly dividing cells at the center of the stem-cell niche, are vital for proper function and maintenance of the RAM. However, temporal aspects of molecular and cellular changes in QC cells and their regulatory mechanisms have not been well studied. In the present study, we investigated temporal changes in QC cell size, expression of QC cell-specific markers (WOX5 and QC25), and genotoxic tolerance and division rate of QC cells in the Arabidopsis primary root. Our data revealed the decreased size of QC cells and the decreased expression of the QC cell-specific markers with root age. We also found that QC cell division frequency increased with root age. Furthermore, our study provides evidence supporting the link between the transition of QC cells from a mitotically quiescent state to the frequently dividing state and the decrease in tolerance to genotoxic stress. © 2019, The Author(s).
URI
http://hdl.handle.net/20.500.11750/9691
DOI
10.1038/s41598-019-40383-2
Publisher
Nature Publishing Group
Related Researcher
  • Author Nam, Hong Gil CBRG(Complex Biology Research Group)
  • Research Interests Plant Aging and Life History; Systems Biology; Complexbiology; Comparative Aging Research
Files:
Collection:
Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles


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