Cited time in webofscience Cited time in scopus

Full metadata record

DC Field Value Language
dc.contributor.author Jang, Hyun Jun -
dc.contributor.author Park, Jeong Hyang -
dc.contributor.author Lee, Ga Seul -
dc.contributor.author Lee, Sung-Bae -
dc.contributor.author Moon, Jeong Hee -
dc.contributor.author Choi, Joon Sig -
dc.contributor.author Lee, Tae Geol -
dc.contributor.author Yoon, Sohee -
dc.date.accessioned 2019-04-18T05:31:00Z -
dc.date.available 2019-04-18T05:31:00Z -
dc.date.created 2019-04-17 -
dc.date.issued 2019-03 -
dc.identifier.citation Mass Spectrometry Letters, v.10, no.1, pp.11 - 17 -
dc.identifier.issn 2233-4203 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/9775 -
dc.description.abstract Drosophila melanogaster (fruits fly) is a representative model system widely used in biological studies because its brain function and basic cellular processes are similar to human beings. The whole head of the fly is often used to obtain the key function in brain-related diseases like degenerative brain diseases; however the biomolecular distribution of the head may be slightly different from that of a brain. Herein, lipid profiles of the head and dissected brain samples of Drosophila were studied using electrospray ionization-mass spectrometry (ESI-MS). According to the sample types, the detection of phospholipid ions was suppressed by triacylglycerol (TAG), or the specific phospholipid signals that are absent in the mass spectrum were measured. The lipid distribution was found to be different in the wild-type and the microRNA-14 deficiency model (miR-14Δ1) with abnormal lipid metabolism. A few phospholipids were also profiled by comparison of the head and the brain in two fly model systems. The mass spectra showed that the phospholipid distributions in the miR-14Δ1 model and the wild-type were different, and principal component analysis revealed a correlation between some phospholipids (phosphatidylethanolamine (PE), phosphatidylinositol (PI), and phosphatidylserine (PS)) in miR-14Δ1. The overall results suggested that brain-related lipids should be profiled using fly samples after dissection for more accurate analysis. © Korean Society for Mass Spectrometry. -
dc.language English -
dc.publisher Korean Society for Mass Spectrometry -
dc.title Comparison of Lipid Profiles in Head and Brain Samples of Drosophila Melanogaster Using Electrospray Ionization Mass Spectrometry (ESI-MS) -
dc.type Article -
dc.identifier.doi 10.5478/MSL.2019.10.1.11 -
dc.identifier.wosid 000464573600002 -
dc.identifier.scopusid 2-s2.0-85066826179 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Mass Spectrometry Letters -
dc.identifier.kciid ART002453693 -
dc.contributor.nonIdAuthor Jang, Hyun Jun -
dc.contributor.nonIdAuthor Park, Jeong Hyang -
dc.contributor.nonIdAuthor Lee, Ga Seul -
dc.contributor.nonIdAuthor Moon, Jeong Hee -
dc.contributor.nonIdAuthor Choi, Joon Sig -
dc.contributor.nonIdAuthor Lee, Tae Geol -
dc.contributor.nonIdAuthor Yoon, Sohee -
dc.identifier.citationVolume 10 -
dc.identifier.citationNumber 1 -
dc.identifier.citationStartPage 11 -
dc.identifier.citationEndPage 17 -
dc.identifier.citationTitle Mass Spectrometry Letters -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor Lipid profile -
dc.subject.keywordAuthor Drosophila sampling -
dc.subject.keywordAuthor Drosophila brain -
dc.subject.keywordAuthor mass spectrometry (MS) -
dc.subject.keywordAuthor electrospray ionization (ESI) -
dc.subject.keywordPlus OF-FLIGHT INSTRUMENT -
dc.subject.keywordPlus MODEL -
dc.subject.keywordPlus COMPLEXES -
dc.subject.keywordPlus DRUGS -
dc.contributor.affiliatedAuthor Jang, Hyun Jun -
dc.contributor.affiliatedAuthor Park, Jeong Hyang -
dc.contributor.affiliatedAuthor Lee, Ga Seul -
dc.contributor.affiliatedAuthor Lee, Sung-Bae -
dc.contributor.affiliatedAuthor Moon, Jeong Hee -
dc.contributor.affiliatedAuthor Choi, Joon Sig -
dc.contributor.affiliatedAuthor Lee, Tae Geol -
dc.contributor.affiliatedAuthor Yoon, Sohee -
Files in This Item:

There are no files associated with this item.

Appears in Collections:
Department of Brain Sciences Laboratory of Neurodegenerative Diseases and Aging 1. Journal Articles

qrcode

  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE