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ALWPs Improve Cognitive Function and Regulate A beta Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer's Disease

  • Nam, Youngpyo
  • Joo, Bitna
  • Lee, Ju-Young
  • Han, Kyung-Min
  • Ryu, Ka-Young
  • Koh, Young Ho
  • Kim, Jeongyeon
  • Koo, Ja Wook
  • We, Young-Man
  • Hoe, Hyang-Sook
  • 2019-08
  • Nam, Youngpyo. (2019-08). ALWPs Improve Cognitive Function and Regulate A beta Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer's Disease. doi: 10.3389/fnmol.2019.00192
  • Frontiers Media S.A.
  • View : 707
  • Download : 113

An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-kappa B Signaling Pathways

  • Lee, Ju-Young
  • 주빛나
  • Nam, Jin Han
  • Nam, Hye Yeon
  • Lee, Wonil
  • Nam, Youngpyo
  • Seo, Yongtaek
  • Kang, Hye-Jin
  • Cho, Hyun-Ji
  • Jang, Young Pyo
  • et al
  • 2018-09
  • Lee, Ju-Young. (2018-09). An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-kappa B Signaling Pathways. doi: 10.3389/fnagi.2018.00269
  • Frontiers Media S.A.
  • View : 710
  • Download : 119

Characterization of age- and stage-dependent impaired adult subventricular neurogenesis in 5XFAD mouse model of Alzheimer’s disease

  • Park, Hyun Ha
  • Kim, Byeong-Hyeon
  • Leem, Seol Hwa
  • Park, Yong Ho
  • Hoe, Hyang-Sook
  • Nam, Yunkwon
  • Kim, Sujin
  • Shin, Soo Jung
  • Moon, Minho
  • 2023-09
  • Park, Hyun Ha. (2023-09). Characterization of age- and stage-dependent impaired adult subventricular neurogenesis in 5XFAD mouse model of Alzheimer’s disease. BMB Reports, 56(9), 520–525. doi: 10.5483/BMBRep.2023-0071
  • The Biochemical Society of the Republic of Korea
  • View : 158
  • Download : 35
  • Lee, Hyun-ju
  • Kang, Sora
  • Jeong, Yoo Joo
  • Park, Jin-Hee
  • Hwang, Jeong-Woo
  • Gu, Chan-Hu
  • Jung, Tae-Mi
  • Oh, Seokjun
  • Jang, Ji-Yeong
  • Hoe, Hyang-Sook
  • 2025-07
  • Molecular Brain, v.18, no.1
  • BioMed Central
  • View : 976
  • Download : 0
  • Lee, Hyun-ju
  • Jeong, Yoo Joo
  • Kim, Jun-Su
  • Kim, Seung-Jae
  • Jo, Unhui
  • Jun, Su Jin
  • Lim, Jongmin
  • Park, Jin-Yeop
  • Lee, Myungji
  • Kim, Donggi
  • et al
  • 2025-06
  • Lee, Hyun-ju. (2025-06). Current Status and Future Directions in the Development of Digital Therapeutic Interventions for Neurodevelopmental Disorders. Clinical Pharmacology and Therapeutics, 117(6), 1632–1636. doi: 10.1002/cpt.3633
  • Wiley
  • View : 63
  • Download : 0

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

  • Ryu, Ka-Young
  • Lee, Hyun-Ju
  • Woo, Hanwoong
  • Kang, Ri-Jin
  • Han, Kyung-Min
  • Park, HyunHee
  • Lee, Sang Min
  • Lee, Ju-Young
  • Jeong, Yoo Joo
  • Nam, Hyun-Wook
  • et al
  • 2019-10
  • Ryu, Ka-Young. (2019-10). Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling. doi: 10.1186/s12974-019-1561-x
  • BioMed Central
  • View : 753
  • Download : 128

Developing theragnostics for Alzheimer's disease: Insights from cancer treatment

  • Lee, Hyun-ju
  • Choi, Hee-Jeong
  • Jeong, Yoo Joo
  • Na, Yoon-Hee
  • Hong, Jin Tae
  • Han, Ji Min
  • Hoe, Hyang-Sook
  • Lim, Key-Hwan
  • 2024-06
  • Lee, Hyun-ju. (2024-06). Developing theragnostics for Alzheimer's disease: Insights from cancer treatment. International Journal of Biological Macromolecules, 269. doi: 10.1016/j.ijbiomac.2024.131925
  • Elsevier
  • View : 159
  • Download : 46
  • Jeong, Yoo Joo
  • Lee, Hyun-ju
  • Kim, Jun-Su
  • Kim, Seung-Jae
  • Jo, Unhui
  • Park, Jin Yeop
  • Jun, Su Jin
  • Lee, Won Seok
  • Song, Mingoo
  • Kim, Donggii
  • et al
  • 2026-01
  • Medicinal Research Reviews, v.46, no.1, pp.316 - 327
  • Wiley
  • View : 71
  • Download : 0

Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling

  • Kim, Jieun
  • Lee, Hyun-ju
  • Park, Seon Kyeong
  • Park, Jin-Hee
  • Jeong, Ha-Ram
  • Lee, Soojung
  • Lee, Heeyong
  • Seol, Eunyoung
  • Hoe, Hyang-Sook
  • 2021-10
  • Kim, Jieun. (2021-10). Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling. doi: 10.3390/ijms221910637
  • Multidisciplinary Digital Publishing Institute (MDPI)
  • View : 432
  • Download : 93
  • Choi, Hee-Jeong
  • Jeong, Yoo Joo
  • Kim, Jieun
  • Hoe, Hyang-Sook
  • 2023-08
  • Choi, Hee-Jeong. (2023-08). EGFR is a potential dual molecular target for cancer and Alzheimer’s disease. Frontiers in Pharmacology, 14. doi: 10.3389/fphar.2023.1238639
  • Frontiers
  • View : 196
  • Download : 17
  • Jeon, Min-Tae
  • Kim, Kyu-Sung
  • Kim, Eun Seon
  • Lee, Suji
  • Kim, Jieun
  • Hoe, Hyang-Sook
  • Kim, Do-Geun
  • 2021-07
  • Jeon, Min-Tae. (2021-07). Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease. Ageing Research Reviews, 68, 101333. doi: 10.1016/j.arr.2021.101333
  • Elsevier BV
  • View : 508
  • Download : 0
  • Lee, Hyun-ju
  • Kim, Se Ha
  • Jung, Tae-Mi
  • Kim, Yu-Jin
  • Gu, Chan-Hu
  • Jeong, Yoo Joo
  • Song, Jeong-Heon
  • Hoe, Hyang-Sook
  • 2025-06
  • Lee, Hyun-ju. (2025-06). Erdafitinib diminishes LPS-mediated neuroinflammatory responses through NLRP3 in wild-type mice. Frontiers in Pharmacology, 16. doi: 10.3389/fphar.2025.1572604
  • Frontiers Media
  • View : 1020
  • Download : 0

Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of AD

  • Lee, Hyun-Ju
  • Hwang, Jeong-Woo
  • Kim, Jieun
  • Jo, A-Ran
  • Park, Jin-Hee
  • Jeong, Yoo Joo
  • Jang, Ji-Yeong
  • Kim, Su-Jeong
  • Song, Jeong-Heon
  • Hoe, Hyang-Sook
  • 2024-10
  • Lee, Hyun-Ju. (2024-10). Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of AD. Frontiers in Immunology, 15. doi: 10.3389/fimmu.2024.1421455
  • Frontiers Media
  • View : 195
  • Download : 24

Felodipine attenuates neuroinflammatory responses and tau hyperphosphorylation through JNK/P38 signaling in tau-overexpressing AD mice

  • Hwang, Jeong-Woo
  • Kim, Jeongha
  • Park, Jin-Hee
  • Nam, Jinhan
  • Jang, Ji-Yeong
  • Jo, Aran
  • Lee, Hyun-Ju
  • Hoe, Hyang-Sook
  • 2024-09
  • Hwang, Jeong-Woo. (2024-09). Felodipine attenuates neuroinflammatory responses and tau hyperphosphorylation through JNK/P38 signaling in tau-overexpressing AD mice. Molecular Brain, 17(1). doi: 10.1186/s13041-024-01137-y
  • BioMed Central
  • View : 274
  • Download : 24
  • Kim, Jieun
  • Han, Jung-Youn
  • Lee, Yujeong
  • Kim, Kipom
  • Choi, Young Pyo
  • Chae, Sehyun
  • Hoe, Hyang-Sook
  • 2023-01
  • Kim, Jieun. (2023-01). Genetic deletion of nitric oxide synthase 2 ameliorates Parkinson’s disease pathology and neuroinflammation in a transgenic mouse model of synucleinopathy. Molecular Brain, 16(1). doi: 10.1186/s13041-023-00996-1
  • BioMed Central
  • View : 163
  • Download : 0
  • Lee, Hyun-ju
  • Jeon, Seong Gak
  • Kim, Jieun
  • Kang, Ri Jin
  • Kim, Seong-Min
  • Han, Kyung-Min
  • Park, HyunHee
  • Kim, Ki-taek
  • Sung, You Me
  • Nam, Hye Yeon
  • et al
  • 2021-03
  • Lee, Hyun-ju. (2021-03). Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease. Aging Cell, 20(3), e13332. doi: 10.1111/acel.13332
  • Blackwell Publishing Inc.
  • View : 487
  • Download : 0

Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD

  • Lee, Hyun-ju
  • Jeong, Ha-Ram
  • Park, Jin-Hee
  • Hoe, Hyang-Sook
  • 2021-09
  • Lee, Hyun-ju. (2021-09). Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD. Biology, 10(9). doi: 10.3390/biology10090938
  • MDPI
  • View : 467
  • Download : 66
  • Lee, Hyun-ju
  • Park, Jin-Hee
  • Hoe, Hyang-Sook
  • 2022-02
  • Lee, Hyun-ju. (2022-02). Idebenone Regulates A beta and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1 beta Axis Activation. Frontiers in Immunology, 13. doi: 10.3389/fimmu.2022.749336
  • Frontiers Media S.A.
  • View : 287
  • Download : 0
  • Lee, Hyun-ju
  • Choi, Tae-Ik
  • Kim, Yong-Min
  • Lee, Soonje
  • Han, Bing
  • Bak, In Seon
  • Moon, Sun Ae
  • Yu, Dae-Yeul
  • Shin, Ki Soon
  • Kwon, Yunhee Kim
  • et al
  • 2021-08
  • Lee, Hyun-ju. (2021-08). Identification of Gng8-expressing cell types in the MHb and IPN. Molecular Psychiatry, 26(8), 3665–3665. doi: 10.1038/s41380-021-01278-9
  • Nature Publishing Group
  • View : 582
  • Download : 0

Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling

  • Lee, Hyun-ju
  • Hoe, Hyang-Sook
  • 2023-04
  • Lee, Hyun-ju. (2023-04). Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling. Pharmacological Research, 190. doi: 10.1016/j.phrs.2023.106725
  • Academic Press
  • View : 173
  • Download : 59
  • Kim, Sujin
  • Shin, Soo Jung
  • Nam, Yunkwon
  • Park, Yong Ho
  • Kim, Byeong-Hyeon
  • Park, Hyun Ha
  • Kumar, Vijay
  • Yoo, Doo-Han
  • Lee, Yong Yook
  • Hoe, Hyang-Sook
  • et al
  • 2024-04
  • Kim, Sujin. (2024-04). Korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in Alzheimer's disease. International Journal of Biological Macromolecules, 263. doi: 10.1016/j.ijbiomac.2024.130516
  • Elsevier
  • View : 152
  • Download : 0

L-DOPA regulates neuroinflammation and Aβ pathology through NEP and ADAM17 in a mouse model of AD

  • Lee, Hyun-ju
  • Nam, Jinhan
  • Hwang, Jeong-Woo
  • Park, Jin-Hee
  • Jeong, Yoo Joo
  • Jang, Ji-Yeong
  • Kim, Su-Jeong
  • Jo, A-Ran
  • Hoe, Hyang-Sook
  • 2024-04
  • Lee, Hyun-ju. (2024-04). L-DOPA regulates neuroinflammation and Aβ pathology through NEP and ADAM17 in a mouse model of AD. Molecular Brain, 17(1). doi: 10.1186/s13041-024-01092-8
  • BioMed Central
  • View : 88
  • Download : 28
  • Kim, Jieun
  • Jeon, Seong Gak
  • Jeong, Ha-Ram
  • Park, HyunHee
  • Kim, Jae-Ick
  • Hoe, Hyang-Sook
  • 2022-11
  • Kim, Jieun. (2022-11). L-Type Ca2+ Channel Inhibition Rescues the LPS-Induced Neuroinflammatory Response and Impairments in Spatial Memory and Dendritic Spine Formation. International Journal of Molecular Sciences, 23(21). doi: 10.3390/ijms232113606
  • MDPI
  • View : 336
  • Download : 0
  • Park, Jin-Hee
  • Hwang, Jeong-Woo
  • Lee, Hyun-ju
  • Jang, Geum Mi
  • Jeong, Yoo Joo
  • Cho, Joonho
  • Seo, Jinsoo
  • Hoe, Hyang-Sook
  • 2023-06
  • Park, Jin-Hee. (2023-06). Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β. Frontiers in Immunology, 14. doi: 10.3389/fimmu.2023.1150940
  • Frontiers Media
  • View : 255
  • Download : 24
  • Nam, Yunkwon
  • Kim, Sujin
  • Kim, Jieun
  • Hoe, Hyang-Sook
  • Moon, Minho
  • 2022-12
  • Nam, Yunkwon. (2022-12). Mesoscopic Mapping of Visual Pathway in a Female 5XFAD Mouse Model of Alzheimer’s Disease. Cells, 11(23). doi: 10.3390/cells11233901
  • MDPI
  • View : 140
  • Download : 0
  • Han, Kyeong-Min
  • 2020
  • Han, Kyeong-Min. (2020). Multi target kinase inhibitor X regulates AD pathology, neuroinflammation, as well as dendritic spinogenesis. doi: 10.22677/thesis.200000322086
  • DGIST
  • View : 508
  • Download : 0
  • 2020-04
  • Moon, Dae Won. (2020-04). Multiplex Protein Imaging with Secondary Ion Mass Spectrometry Using Metal Oxide Nanoparticle-Conjugated Antibodies. ACS Applied Materials & Interfaces, 12(15), 18056–18064. doi: 10.1021/acsami.9b21800
  • American Chemical Society
  • View : 936
  • Download : 0
  • Kim, Jieun
  • Lee, Hyun-ju
  • Park, Jin-Hee
  • Cha, Byung-Yoon
  • Hoe, Hyang-Sook
  • 2022-07
  • Kim, Jieun. (2022-07). Nilotinib modulates LPS-induced cognitive impairment and neuroinflammatory responses by regulating P38/STAT3 signaling. Journal of Neuroinflammation, 19(1). doi: 10.1186/s12974-022-02549-0
  • BioMed Central
  • View : 310
  • Download : 0
  • Lee, Hyun-ju
  • Hwang, Jeong-Woo
  • Park, Jin-Hee
  • Jeong, Yoo Joo
  • Jang, Ji-Yeong
  • Hoe, Hyang-Sook
  • 2023-08
  • Lee, Hyun-ju. (2023-08). Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD. Molecular Brain, 16(1). doi: 10.1186/s13041-023-01051-9
  • BioMed Central
  • View : 109
  • Download : 0
  • Lee, Hyun-ju
  • Park, Jin-Hee
  • Trotter, Justin H.
  • Maher, James N.
  • Keenoy, Kathleen E.
  • Jang, You Mi
  • Lee, Youngeun
  • Kim, Jae-Ick
  • Weeber, Edwin J.
  • Hoe, Hyang-Sook
  • 2023-02
  • Lee, Hyun-ju. (2023-02). Reelin and APP Cooperatively Modulate Dendritic Spine Formation In Vitro and In Vivo. Experimental Neurobiology, 32(1), 42–55. doi: 10.5607/en22044
  • 한국뇌신경과학회
  • View : 329
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Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD

  • Han, Kyung-Min
  • Kang, Ri Jin
  • Jeon, Hyongjun
  • Lee, Hyun-ju
  • Lee, Ji-Soo
  • Park, HyunHee
  • Jeon, Seong Gak
  • Suk, Kyoungho
  • Seo, Jinsoo
  • Hoe, Hyang-Sook
  • 2020-07
  • Han, Kyung-Min. (2020-07). Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD. doi: 10.3390/cells9071655
  • MDPI AG
  • View : 635
  • Download : 193
  • Lee, Hyun-ju
  • Choi, Tae-Ik
  • Kim, Yong-Min
  • Lee, Soonje
  • Han, Bing
  • Bak, In Seon
  • Moon, Sun Ae
  • Yu, Dae-Yeul
  • Shin, Ki Soon
  • Kim Kwon, Yunhee
  • et al
  • 2021-08
  • Lee, Hyun-ju. (2021-08). Regulation of habenular G-protein gamma 8 on learning and memory via modulation of the central acetylcholine system. Molecular Psychiatry, 26(8), 3737–3750. doi: 10.1038/s41380-020-00893-2
  • Nature Publishing Group
  • View : 749
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Repurposing ibrutinib: therapeutic effects and implications for translational approaches in Alzheimer's disease

  • Lee, Hyun-ju
  • Hoe, Hyang-Sook
  • 2023-10
  • Lee, Hyun-ju. (2023-10). Repurposing ibrutinib: therapeutic effects and implications for translational approaches in Alzheimer's disease. Neural Regeneration Research, 18(10), 2194–2195. doi: 10.4103/1673-5374.369108
  • Neural Regeneration Research
  • View : 61
  • Download : 24

Sorafenib Modulates the LPS- and A beta-Induced Neuroinflammatory Response in Cells, Wild-Type Mice, and 5xFAD Mice

  • Kim, Jieun
  • Park, Jin-Hee
  • Park, Seon Kyeong
  • Hoe, Hyang-Sook
  • 2021-05
  • Kim, Jieun. (2021-05). Sorafenib Modulates the LPS- and A beta-Induced Neuroinflammatory Response in Cells, Wild-Type Mice, and 5xFAD Mice. doi: 10.3389/fimmu.2021.684344
  • Frontiers Media S.A.
  • View : 492
  • Download : 132

The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome

  • Kim, Jieun
  • Park, Jin-Hee
  • Shah, Keshvi
  • Mitchell, Scott John
  • Cho, Kwangwook
  • Hoe, Hyang-Sook
  • 2021-10
  • Kim, Jieun. (2021-10). The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome. Frontiers in Aging Neuroscience, 13. doi: 10.3389/fnagi.2021.754123
  • Frontiers Media S.A.
  • View : 311
  • Download : 105

The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta

  • Chae, Sehyun
  • Lee, Hyun-ju
  • Lee, Ha-Eun
  • Kim, Jieun
  • Jeong, Yoo Joo
  • Lin, Yuxi
  • Kim, Hye Yun
  • Leriche, Geoffray
  • Ehrlich, Rachel S.
  • Lingl, Sascha Castro
  • et al
  • 2024-08
  • Chae, Sehyun. (2024-08). The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta. Journal of Neuroinflammation, 21(1). doi: 10.1186/s12974-024-03180-x
  • BioMed Central
  • View : 226
  • Download : 26

The MAO Inhibitor Tranylcypromine Alters LPS- and A beta-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD

  • Park, HyunHee
  • Han, Kyung-Min
  • Jeon, Hyongjun
  • Lee, Ji-Soo
  • Lee, Hyunju
  • Jeon, Seong Gak
  • Park, Jin-Hee
  • Kim, Yu Gyung
  • Lin, Yuxi
  • Lee, Young-Ho
  • et al
  • 2020-09
  • Park, HyunHee. (2020-09). The MAO Inhibitor Tranylcypromine Alters LPS- and A beta-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD. doi: 10.3390/cells9091982
  • NLM (Medline)
  • View : 581
  • Download : 91
  • Lee, Hyun-ju
  • Woo, Hanwoong
  • Lee, Ha-Eun
  • Jeon, Hyongjun
  • Ryu, Ka-Young
  • Nam, Jin han
  • Jeon, Seong Gak
  • Park, HyunHee
  • Lee, Ji-Soo
  • Han, Kyung-Min
  • et al
  • 2020-11
  • Lee, Hyun-ju. (2020-11). The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation. doi: 10.1016/j.freeradbiomed.2020.08.030
  • Elsevier Inc.
  • View : 565
  • Download : 0
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