Cited 3 time in webofscience Cited 2 time in scopus

Augmented Mechanical Forces of the Surface-Modified Nanoporous Acupuncture Needles Elicit Enhanced Analgesic Effects

Title
Augmented Mechanical Forces of the Surface-Modified Nanoporous Acupuncture Needles Elicit Enhanced Analgesic Effects
Authors
Bae, Sun-JeongLim, JunsikLee, SangminChoi, HansaemJang, Jae-HwanKim, Yu-KangOh, Ju-YoungPark, Jeong HunJung, Hyuk-SangChae, YounbyungIn, Su-IlPark, Hi-Joon
DGIST Authors
In, Su-Il
Issue Date
2019-06
Citation
Frontiers in Neuroscience, 13(JUN), 652
Type
Article
Article Type
Article
Author Keywords
acupuncture analgesiananoporous needlemuscleconnective tissuetorquecomplete Freund&aposs adjuvant
Keywords
LOW-BACK-PAINCONNECTIVE-TISSUESIGNALING PATHWAYELECTROACUPUNCTUREADENOSINEPOINTS
ISSN
1662-453X
Abstract
Over the past several decades, clinical studies have shown significant analgesic effects of acupuncture. The efficacy of acupuncture treatment has improved with the recent development of nanoporous needles (PN), which are produced by modifying the needle surface using nanotechnology. Herein, we showed that PN at acupoint ST36 produces prolonged analgesic effects in an inflammatory pain model; the analgesic effects of PN acupuncture were sustained over 2 h, while those using a conventional needle (CN) lasted only 30 min. In addition, the PN showed greater therapeutic effects than CN after 10 acupuncture treatments once per day for 10 days. We explored how the porous surface of the PN contributes to changes in local tissue, which may in turn result in enhanced analgesic effects. We showed that the PN has greater rotational torque and pulling force than the CN, particularly at acupoints ST36 and LI11, situated on thick muscle layers. Additionally, in ex vivo experiments, the PN showed greater winding of subcutaneous connective tissues and muscle layers. Our results suggest that local mechanical forces are augmented by the PN and its nanoporous surface, contributing to the enhanced and prolonged analgesic effects of PN acupuncture.
URI
http://hdl.handle.net/20.500.11750/10098
DOI
10.3389/fnins.2019.00652
Publisher
Frontiers Media S.A.
Related Researcher
  • Author In, Su-Il Green and Renewable Energy for Endless Nature(GREEN) Lab
  • Research Interests CO2 conversion to hydrocarbon fuels; Water splitting for hydrogen generation; Quantum dot devices; Dye sensitized solar cells; Environmental remediation; Synthesis of functional nanomaterials; CO2 연료전환; 수소생산을 위한 광전기화학적 물분해; 양자점 태양전지; 염료감응 태양전지; 공해물질 저감연구; 기능성 나노소재 개발
Files:
Collection:
Department of Energy Science and EngineeringGreen and Renewable Energy for Endless Nature(GREEN) Lab1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE