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DC Field Value Language Baik, Seung-Hoon - Bae, Ok-Nam - Yu, Seong-Woon - 2019-07-22T02:31:37Z - 2019-07-22T02:31:37Z - 2018-03-29 - 2012-11 -
dc.identifier.citation Quantitative Bio-Science, v.31, no.2, pp.133 - 137 -
dc.identifier.issn 2288-1344 -
dc.identifier.uri -
dc.identifier.uri -
dc.description.abstract Mitochondria are dynamic cellular organelles with Janus-faced functions that can be beneficial or deleterious to cells. Mounting evidences indicate the involvement of mitochondria dysfunction in an early stage of neurodegeneration. Parkinson’s disease (PD) is the debilitating neurodegenerative disorder that causes severe motor function impairment. Accumulating body of evidence suggests the mitochondrial dysfunction in the pathogenesis of PD. Genetic mutations in parkin have been reported in large numbers of families. In this study, we used parkin null mice model to examine the effect of parkin deficiency on mitochondrial function at basal state. Brain mitochondria were isolated from brain of young (8-10 weeks old) parkin null mice as well as wildtype littermate mice and mitochondrial respiration rates were measured as a biochemical marker of bioenergetics. Only a slight reduction in respiration rate was observed in parkin null mice compared with wildtype mice, suggesting that parkin deficiency-associated mitochondrial dysfunction at the basal state was not initiated at this young age. Evaluation at different time points should be carried out for further study. -
dc.language English -
dc.publisher 자연과학연구소 -
dc.title Mitochondrial Bioenergetics of Brain Mitochondria Isolated from Parkin Null Mice -
dc.type Article -
dc.type.local Article(Domestic) -
dc.type.rims ART -
dc.description.journalClass 2 -
dc.citation.publicationname Quantitative Bio-Science -
dc.contributor.nonIdAuthor Baik, Seung-Hoon -
dc.contributor.nonIdAuthor Bae, Ok-Nam -
dc.identifier.citationVolume 31 -
dc.identifier.citationNumber 2 -
dc.identifier.citationStartPage 133 -
dc.identifier.citationEndPage 137 -
dc.identifier.citationTitle Quantitative Bio-Science -
dc.description.isOpenAccess Y -
dc.subject.keywordAuthor Mitochondria -
dc.subject.keywordAuthor Bioenergetics -
dc.subject.keywordAuthor Parkin -
dc.subject.keywordAuthor Parkin null mice -
dc.subject.keywordAuthor Parkinson’s disease -
dc.contributor.affiliatedAuthor Baik, Seung-Hoon -
dc.contributor.affiliatedAuthor Bae, Ok-Nam -
dc.contributor.affiliatedAuthor Yu, Seong-Woon -
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Department of Brain Sciences Laboratory of Neuronal Cell Death 1. Journal Articles


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