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An adiponectin receptor agonist antibody stimulates glucose uptake and fatty-acid oxidation by activating AMP-activated protein kinase

Title
An adiponectin receptor agonist antibody stimulates glucose uptake and fatty-acid oxidation by activating AMP-activated protein kinase
Authors
Jung, DokyungBucher, FelicitasRyu, SuyeonJeong, JongwonLee, Beom YongJeong, YoungtaeKim, Minseok S.Oh, Yong-SeokBaek, Moon-ChangYoon, Jong HyukYea, Kyungmoo
DGIST Authors
Jeong, YoungtaeKim, Minseok S.Oh, Yong-SeokYea, Kyungmoo
Issue Date
2020-02
Citation
Cytokine, 126, 154863
Type
Article
Article Type
Article
Author Keywords
AdiponectinAgonist antibodyDiabetesAMPK
Keywords
INSULIN-RESISTANCEOBESITYCELLS
ISSN
1043-4666
Abstract
Adiponectin (Ad) is a representative adipocytokine that regulates energy homeostasis including glucose transport and lipid oxidation through activation of AMP-activated protein kinase (AMPK) pathways. Plasma levels of Ad are reduced in obesity, which contributes to type 2 diabetes. Therefore, agents that activate the Ad signaling pathway could ameliorate metabolic diseases such as type 2 diabetes. Here, we report the identification of a high-affinitive agonist antibody against Ad receptors. The antibody was selected by using phage display of human combinatorial antibody libraries. The selected antibody induced phosphorylation of the acetyl-CoA carboxylase (ACC) and AMPK in skeletal muscle cells and stimulated glucose uptake and fatty-acid oxidation (FAO) in myotubes. In addition, the antibody significantly lowered blood glucose levels during a glucose challenge in normal mice as well as basal blood glucose levels in a type 2 diabetic mouse model. Taken together, these results suggest that the agonist antibody could be a promising therapeutic agent for the treatment of metabolic syndrome such as type 2 diabetes. © 2019 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/10950
DOI
10.1016/j.cyto.2019.154863
Publisher
Elsevier
Related Researcher
  • Author Oh, Yong-Seok Molecular Psychiatry Lab
  • Research Interests Monoaminergic regulation of the CNS and mood;anxiety disorder; 모노아민 (세로토닌, 도파민)에 의한 신경조절과 기분;불안 장애 기전 연구
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Collection:
Department of New BiologyLab of Stem Cell Biology & Cancer Precision Medicine1. Journal Articles
Department of New BiologyBioDr. Lab - Nanobiomedicine1. Journal Articles
Department of Brain and Cognitive SciencesMolecular Psychiatry Lab1. Journal Articles
Department of New BiologyProtein Engineering Lab1. Journal Articles


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