Cited 3 time in webofscience Cited 3 time in scopus

Gut Microbial Metabolites Induce Changes in Circadian Oscillation of Clock Gene Expression in the Mouse Embryonic Fibroblasts

Title
Gut Microbial Metabolites Induce Changes in Circadian Oscillation of Clock Gene Expression in the Mouse Embryonic Fibroblasts
Authors
Ku, KyojinPark, InahKim, DoyeonKim, JeongahJang, SangwonChoi, MijungChoe, Han KyoungKim, Kyungjin
DGIST Authors
Ku, Kyojin; Park, Inah; Kim, Doyeon; Kim, Jeongah; Jang, Sangwon; Choi, Mijung; Choe, Han Kyoung; Kim, Kyungjin
Issue Date
2020-03
Citation
Molecules and Cells, 43(3), 276-285
Type
Article
Article Type
Article
Author Keywords
3-(4-hydroxyphenyl)propionic acid3-phenylpropionic acidBmal1circadian rhythmgut microbiomePer2real-time bioluminescence recording
Keywords
AROMATIC-AMINO-ACIDSTEMPERATUREENTRAINMENTIMPACT
ISSN
1016-8478
Abstract
Circadian rhythm is an endogenous oscillation of about 24-h period in many physiological processes and behaviors. This daily oscillation is maintained by the molecular clock machinery with transcriptional-translational feedback loops mediated by clock genes including Period2 (Per2) and Bmal1. Recently, it was revealed that gut microbiome exerts a significant impact on the circadian physiology and behavior of its host; however, the mechanism through which it regulates the molecular clock has remained elusive. 3-(4-hydroxyphenyl)propionic acid (4-OH-PPA) and 3-phenylpropionic acid (PPA) are major metabolites exclusively produced by Clostridium sporogenes and may function as unique chemical messengers communicating with its host. In the present study, we examined if two C. sporogenes-derived metabolites can modulate the oscillation of mammalian molecular clock. Interestingly, 4-OH-PPA and PPA increased the amplitude of both PER2 and Bmal1 oscillation in a dosedependent manner following their administration immediately after the nadir or the peak of their rhythm. The phase of PER2 oscillation responded differently depending on the mode of administration of the metabolites. In addition, using an organotypic slice culture ex vivo, treatment with 4-OH-PPA increased the amplitude and lengthened the period of PER2 oscillation in the suprachiasmatic nucleus and other tissues. In summary, two C. sporogenes-derived metabolites are involved in the regulation of circadian oscillation of Per2 and Bmal1 clock genes in the host's peripheral and central clock machineries.
URI
http://hdl.handle.net/20.500.11750/11655
DOI
10.14348/molcells.2020.2309
Publisher
한국분자세포생물학회
Related Researcher
  • Author Choe, Han Kyoung Laboratory of Animal Behavior and Circadian rhythm
  • Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
Files:
Collection:
Department of Brain and Cognitive SciencesLaboratory of Animal Behavior and Circadian rhythm1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE