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  Department of Brain Sciences Synapse Disorder Laboratory

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Article
Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylation
  • Jung, Hyeji ; 
  • Kim, Byeongchan ; 
  • Jang, Gyubin ; 
  • Lee, Hyojeong ; 
  • Kim, Younghye ; 
  • Kim, Hyeonho ; 
  • Lee, Heaji ; 
  • Kim, Dongwook ; 
  • Yang, Yeji ; 
  • Jeong, Woo Chan ; 
    • et al
  • 2025-10
  • Molecular Psychiatry
  • Nature Publishing Group
  • View : 34
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The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions

Article
The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions
  • Jung, Hyeji ; 
  • Kim, Byeongchan ; 
  • Jang, Gyubin ; 
  • Kim, Hyeonho ; 
  • Lee, Ae-Ree ; 
  • Yoon, Sung-Hyun ; 
  • Lee, Kyung-Seo ; 
  • Hyun, Gaeun ; 
  • Kim, Younghye ; 
  • Ko, Jaewon ; 
    • et al
  • 2025-05
  • Jung, Hyeji. (2025-05). The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions. Cell Reports, 44(5). doi: 10.1016/j.celrep.2025.115656
  • Cell Press
  • View : 331
  • Download : 80
Article
EphB2 receptor tyrosine kinase-mediated excitatory synaptic functions are negatively modulated by MDGA2
  • Kim, Hyeonho ; 
  • Jeon, Younghyeon ; 
  • Kim, Seunghye ; 
  • Guo, Yuxuan ; 
  • Kim, Dongwook ; 
  • Jang, Gyubin ; 
  • Brasch, Julia ; 
  • Um, Ji Won ; 
  • Ko, Jaewon
  • 2025-07
  • Kim, Hyeonho. (2025-07). EphB2 receptor tyrosine kinase-mediated excitatory synaptic functions are negatively modulated by MDGA2. Progress in Neurobiology, 250. doi: 10.1016/j.pneurobio.2025.102772
  • Elsevier
  • View : 338
  • Download : 0
Article
Multifarious astrocyte–neuron dialog in shaping neural circuit architecture
  • 2025-01
  • Ngoc, Khai Huynh. (2025-01). Multifarious astrocyte–neuron dialog in shaping neural circuit architecture. Trends in Cell Biology, 35(1), 74–87. doi: 10.1016/j.tcb.2024.05.002
  • Elsevier
  • View : 419
  • Download : 0
Article
MDGAs perform activity- dependent synapse type- specific suppression via distinct extracellular mechanisms
  • Kim, Seungjoon ; 
  • Jang, Gyubin ; 
  • Kim, Hyeonho ; 
  • Lim, Dongseok ; 
  • Han, Kyung Ah ; 
  • Um, Ji Won ; 
  • Ko, Jaewon
  • 2024-06
  • Proceedings of the National Academy of Sciences of the United States of America, v.121, no.26
  • National Academy of Sciences
  • View : 382
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Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons

Article
Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons
  • Han, Kyung Ah ; 
  • Yoon, Taek Han ; 
  • Kim, Jinhu ; 
  • Lee, Jusung ; 
  • Lee, Ju Yeon ; 
  • Jang, Gyubin ; 
  • Um, Ji Won ; 
  • Kim, Jong Kyoung ; 
  • Ko, Jaewon
  • 2024-03
  • Han, Kyung Ah. (2024-03). Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons. Nature Communications, 15(1), 1624. doi: 10.1038/s41467-024-45695-0
  • Nature Publishing Group
  • View : 319
  • Download : 52
Article
Intracellular signaling mechanisms that shape postsynaptic GABAergic synapses
  • 2023-08
  • Jung, Hyeji. (2023-08). Intracellular signaling mechanisms that shape postsynaptic GABAergic synapses. Current Opinion in Neurobiology, 81. doi: 10.1016/j.conb.2023.102728
  • Elsevier
  • View : 515
  • Download : 0
Article
LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment
  • Jung, Hyeji ; 
  • Lee, Dongsu ; 
  • You, Heejung ; 
  • Lee, Myungha ; 
  • Kim, Hyeonho ; 
  • Cheong, Eunji ; 
  • Um, Ji Won
  • 2023-04
  • Jung, Hyeji. (2023-04). LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment. Scientific Reports, 13(1). doi: 10.1038/s41598-023-32798-9
  • Nature Publishing Group
  • View : 289
  • Download : 31
Article
Differential Regional Vulnerability of the Brain to Mild Neuroinflammation Induced by Systemic LPS Treatment in Mice
  • Jung, Hyeji ; 
  • Lee, Hyojeong ; 
  • Kim, Dongwook ; 
  • Cheong, Eunji ; 
  • Hyun, Young-Min ; 
  • Yu, Je-Wook ; 
  • Um, Ji Won
  • 2022-05
  • Jung, Hyeji. (2022-05). Differential Regional Vulnerability of the Brain to Mild Neuroinflammation Induced by Systemic LPS Treatment in Mice. Journal of Inflammation Research, 15, 3053–3063. doi: 10.2147/JIR.S362006
  • Dove Medical Press Ltd
  • View : 437
  • Download : 0
Article
Reassessing Synaptic Adhesion Pathways
  • 2022-07
  • 임동석. (2022-07). Reassessing Synaptic Adhesion Pathways. Trends in Neurosciences, 45(7), 517–528. doi: 10.1016/j.tins.2022.04.004
  • Elsevier
  • View : 636
  • Download : 0
Article
SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice
  • Chehadeh, Salima El ; 
  • Han, Kyung Ah ; 
  • Kim, Dongwook ; 
  • Jang, Gyubin ; 
  • Bakhtiari, Somayeh ; 
  • Lim, Dongseok ; 
  • Kim, Hee Young ; 
  • Kim, Jinhu ; 
  • Kim, Hyeonho ; 
  • Wynn, Julia ; 
    • et al
  • 2022-07
  • Chehadeh, Salima El. (2022-07). SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice. Nature Communications, 13(1). doi: 10.1038/s41467-022-31566-z
  • Nature Publishing Group
  • View : 647
  • Download : 0
Article
MDGA1 negatively regulates amyloid precursor protein-mediated synaptic inhibition in the hippocampus
  • Kim, Jinhu ; 
  • Kim, Seungjoon ; 
  • Kim, Hyeonho ; 
  • Hwang, In-Wook ; 
  • Bae, Sungwon ; 
  • Karki, Sudeep ; 
  • Kim, Dongwook ; 
  • Ogelman, Robert ; 
  • Bang, Geul ; 
  • Kim, Jin Young ; 
    • et al
  • 2022-01
  • Kim, Jinhu. (2022-01). MDGA1 negatively regulates amyloid precursor protein-mediated synaptic inhibition in the hippocampus. doi: 10.1073/pnas.2115326119
  • National Academy of Sciences
  • View : 918
  • Download : 0
Article
LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits
  • Kim, Jinhu ; 
  • Park, Dongseok ; 
  • Seo, Na-Young ; 
  • Yoon, Taek Han ; 
  • Kim, Gyu Hyun ; 
  • Lee, Sang-Hoon ; 
  • Seo, Jinsoo ; 
  • Um, Ji Won ; 
  • Lee, Kea Joo ; 
  • Ko, Jaewon
  • 2022-01
  • Kim, Jinhu. (2022-01). LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits. doi: 10.1073/pnas.2110196119
  • National Academy of Sciences
  • View : 861
  • Download : 0
Article
IQSEC3 deletion impairs fear memory through upregulation of ribosomal S6 kinase 1 signaling in the hippocampus
  • Kim, Dongwook ; 
  • Jung, Hyeji ; 
  • Shirai Yoshinori ; 
  • Kim, Hyeonho ; 
  • Kim, Jinhu ; 
  • Lim, Dongseok ; 
  • Takuma Mori ; 
  • Lee, Hyojeong ; 
  • Park, Dongseok ; 
  • Kim, Hee Young ; 
    • et al
  • 2022-05
  • Kim, Dongwook. (2022-05). IQSEC3 deletion impairs fear memory through upregulation of ribosomal S6 kinase 1 signaling in the hippocampus. Biological Psychiatry, 91(9), 821–831. doi: 10.1016/j.biopsych.2021.12.016
  • Elsevier BV
  • View : 866
  • Download : 0

Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior

Article
Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior
  • Kim, Seungjoon ; 
  • Park, Dongseok ; 
  • Kim, Jinhu ; 
  • Kim, Dongwook ; 
  • Kim, Hyeonho ; 
  • Jung, Hyeji ; 
  • Mori, Takuma ; 
  • Lee, Dongsu ; 
  • Hong, Sookyung ; 
  • Jeon, Jongcheol ; 
    • et al
  • 2021-07
  • Kim, Seungjoon. (2021-07). Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior. Cell Reports, 36(3). doi: 10.1016/j.celrep.2021.109417
  • Cell Press
  • View : 720
  • Download : 251

Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies

Article
Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies
  • Kim, Seungjoon ; 
  • Kang, Mooseok ; 
  • Park, Dongseok ; 
  • Lee, Ae-Ree ; 
  • Betz, Heinrich ; 
  • Ko, Jaewon ; 
  • Chang, Iksoo ; 
  • Um, Ji Won
  • 2021-02
  • Kim, Seungjoon. (2021-02). Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies. doi: 10.1016/j.isci.2021.102037
  • Cell Press
  • View : 836
  • Download : 573
Article
LAR-RPTPs Directly Interact with Neurexins to Coordinate Bidirectional Assembly of Molecular Machineries
  • Han, Kyung Ah ; 
  • Kim, YJ ; 
  • Yoon, Taek Han ; 
  • Kim, Hyeonho ; 
  • Bae, Sungwon ; 
  • Um, Ji Won ; 
  • Choi, SY ; 
  • Ko, Jaewon
  • 2020-10
  • Han, Kyung Ah. (2020-10). LAR-RPTPs Directly Interact with Neurexins to Coordinate Bidirectional Assembly of Molecular Machineries. doi: 10.1523/JNEUROSCI.1091-20.2020
  • Society for Neuroscience
  • View : 864
  • Download : 0
Article
Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function
  • 2021-05
  • Kim, Hee Young. (2021-05). Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function. Progress in Neurobiology, 200. doi: 10.1016/j.pneurobio.2020.101983
  • Pergamon Press Ltd.
  • View : 881
  • Download : 0

Protocol for Quantitative Analysis of Synaptic Vesicle Clustering in Axons of Cultured Neurons

Article
Protocol for Quantitative Analysis of Synaptic Vesicle Clustering in Axons of Cultured Neurons
  • 2020-09
  • Um, Ji Won. (2020-09). Protocol for Quantitative Analysis of Synaptic Vesicle Clustering in Axons of Cultured Neurons. STAR Protocols, 1(2), 100095. doi: 10.1016/j.xpro.2020.100095
  • Elsevier
  • View : 824
  • Download : 327

Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice

Article
Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice
  • 2020-10
  • Han, Kyung Ah. (2020-10). Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice. doi: 10.1186/s13229-020-00392-9
  • BioMed Central Ltd
  • View : 871
  • Download : 336
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