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Exosome-based photoacoustic imaging guided photodynamic and immunotherapy for the treatment of pancreatic cancer

Exosome-based photoacoustic imaging guided photodynamic and immunotherapy for the treatment of pancreatic cancer
Jang, YonghoKim, HaeminYoon, SemiLee, HohyeonHwang, JangsunJung, JaehunChang, Jin HoChoi, JonghoonKim, Hyuncheol
Issued Date
Journal of Controlled Release, v.330, pp.293 - 304
Author Keywords
ExosomeImmunotherapyPhotoacousticsPhotodynamic therapyTumor targeting
Emerging technologiesGenetic modificationsInnate immune systemsPhoto-acoustic imagingCytologyCellsControlled drug deliveryDiseasesPhotoacoustic effectPhotodynamic therapyPhotosensitizersProteinsTargeted drug deliveryTumorsCell-to-cell communicationCombination therapyDrug delivery carrierDrug delivery vehicles
Exosomes, which are released from all cells and take part in cell-to-cell communication, have been utilized as drug delivery vehicles in many recent studies. Immunotherapy is an emerging technology which uses patients' innate immune systems. In immunotherapy, immune cells are stimulated through antibodies, the other immune cells and genetic modifications for the purposes of, for instance, cancer therapy. In this study, tumor-derived re-assembled exosome (R-Exo) was simultaneously utilized as both a drug delivery carrier and an immunostimulatory agent. A chlorin e6 photosensitizer was loaded into tumor-derived exosomes during exosomal re-assembly. After this modification, R-Exo retains its original average size and has the same membrane proteins, which allows for targeting of tumor cells. Chlorin e6-loaded R-Exo (Ce6-R-Exo) can be visualized by photoacoustic imaging and can efficiently generate reactive oxygen species inside tumor cells under laser irradiation. In addition, Ce6-R-Exo increased the release of cytokines from immune cells, which indicates that these modified exosomes can be used as an immunotherapeutic agent. In conclusion, we developed a novel strategy that enables photoacoustic imaging-guided photodynamic and immune-combination therapy for the treatment of cancer with tumor-derived Ce6-R-Exo. © 2020 Elsevier B.V.
Elsevier BV
Related Researcher
  • 장진호 Chang, Jin Ho 전기전자컴퓨터공학과
  • Research Interests Biomedical Imaging; Signal and Image Processing; Ultrasound Imaging System; Ultrasound Transducer; Photoacoustic Imaging
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Department of Electrical Engineering and Computer Science Medical Acoustic Fusion Innovation Lab. 1. Journal Articles


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