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Anorexia, anhedonia and depression in rats by chronic dexamethasone.

Title
Anorexia, anhedonia and depression in rats by chronic dexamethasone.
Author(s)
Kim, Do YunLee, Sung HoKim, Jin YoungKoo, Jae HyungKim, Soung-MinKim, Kyung-NyunLee, Jong-HoJahng, Jeong Won
DGIST Authors
Kim, Do YunLee, Sung HoKim, Jin YoungKoo, Jae HyungKim, Soung-MinKim, Kyung-NyunLee, Jong-HoJahng, Jeong Won
Issued Date
2015-06
Type
Article
ISSN
2220-6655
Abstract
This study investigated a causal relationship between anorexia and anhedonia in an animal model of stress, and
examined if the stress-induced anorexia and/or anhedonia is accompanied by changes in sweet receptor
expression in taste cells. Rats received daily injections of dexamethasone (0.1 or 1 mg/kg) or saline, mimicking
stress status. Anhedonia was assessed by measuring preferences for sweet and palatable foods at different time
points of drug injections. Rats were subjected to behavioral sessions to assess depression-like behaviors after 3
days or 4 weeks of daily drug injections. Decreased food intake was observed from the first day of
dexamethasone injection in a dose dependent manner, and persisted throughout the whole experimental period,
revealing anorectic property of the drug treatment. Sucrose preference was decreased in the 2nd week, and
cookie consumption on the 4th day, of drug treatment, as the earliest time point, respectively. Increased
immobility during forced swimming test was observed at the 3rd week, but not on the 4th day, of drug treatment.
Sweet receptors, T1R2 and T1R3, expression in the circumvallate papillae was not affected by dexamethasone
treatment. It is concluded that the development of anhedonia, possibly caused by anorexia, is a pre-symptomatic
feature of depression in rats treated with chronic dexamethasone, and its pathophysiologic mechanisms may not
comprise changes in sweet receptor expression in taste cells.
URI
http://hdl.handle.net/20.500.11750/13333
DOI
10.12692/ijb/6.11.32-41
Publisher
International Network for natural Sciences
Related Researcher
  • 구재형 Koo, JaeHyung 뉴바이올로지학과
  • Research Interests 장내미생물/감염균 유래 대사체를 통한 신경염증; 알츠하이머병; 우울증; 당뇨/비만; 대사체/수용체 상호작용에 의한 대사연구
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Department of New Biology Brain-Immune Axis Laboratory 1. Journal Articles

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