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Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation

Title
Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
Authors
Kim, KyungsooYoo, Seung JunKim, So YeunLee, TaejuLim, Sung‐HoJang, Jae EunJe, MinkyuMoon, CheilChoi, Ji-Woong
DGIST Authors
Kim, Kyungsoo; Yoo, Seung Jun; Kim, So Yeun; Lee, Taeju; Lim, Sung‐Ho; Jang, Jae Eun; Je, Minkyu; Moon, CheilChoi, Ji-Woong
Issue Date
2021-07
Citation
Scientific Reports, 11(1), 14048
Type
Article
Keywords
PROMOTES FUNCTIONAL RECOVERYCEREBRAL-ARTERY OCCLUSIONPLASTICITYISCHEMIARATMICROELECTRODESACTIVATIONSYMPTOMSMODELTIME
ISSN
2045-2322
Abstract
As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery for stroke rehabilitation. In this study, we propose an engineering approach with subthreshold electrical stimulation (STES) to bring functional recovery. Here, we show a low level of electrical stimulation boosted causal excitation in connected neurons and strengthened the synaptic weight in a simulation study. We found that STES with motor training enhanced functional recovery after stroke in vivo. STES was shown to induce neural reconstruction, indicated by higher neurite expression in the stimulated regions and correlated changes in behavioral performance and neural spike firing pattern during the rehabilitation process. This will reduce the energy consumption of implantable devices and the side effects caused by stimulating unwanted brain regions. © 2021, The Author(s).
URI
http://hdl.handle.net/20.500.11750/13995
DOI
10.1038/s41598-021-93354-x
Publisher
Nature Publishing Group
Related Researcher
  • Author Choi, Ji-Woong CSP(Communication and Signal Processing) Lab
  • Research Interests Communication System; Signal Processing; Communication Circuit Design; 생체 신호 통신 및 신호 처리; 뇌-기계 인터페이스(BMI); 차세대 교차계층 통신 및 신호 처리; 5G 모바일 통신
Files:
Collection:
Department of Brain SciencesETC1. Journal Articles
Department of Electrical Engineering and Computer ScienceAdvanced Electronic Devices Research Group(AEDRG) - Jang Lab.1. Journal Articles
Department of Brain SciencesLaboratory of Chemical Senses1. Journal Articles
Department of Electrical Engineering and Computer ScienceCSP(Communication and Signal Processing) Lab1. Journal Articles


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