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A Magnetically Powered Stem Cell-Based Microrobot for Minimally Invasive Stem Cell Delivery via the Intranasal Pathway in a Mouse Brain

A Magnetically Powered Stem Cell-Based Microrobot for Minimally Invasive Stem Cell Delivery via the Intranasal Pathway in a Mouse Brain
Jeon, SungwoongPark, Sun HwaKim, Eun HeeKim, Jin-youngKim, Sung WonChoi, Hongsoo
DGIST Authors
Jeon, Sungwoong; Park, Sun Hwa; Kim, Eun Hee; Kim, Jin-young; Kim, Sung Won; Choi, Hongsoo
Issue Date
Advanced Healthcare Materials, 10(19), 2100801
Author Keywords
magnetic actuationmicrorobotsstem cell deliverysuperparamagnetic iron oxide nanoparticlesintranasal administration
CytologyData communication equipmentIron oxidesMagnetic nanoparticlesMicrorobotsNeuronsPosition controlTissueCentral nervous systemsEffective approachesExternal magnetic fieldMicrofluidic channelMinimally invasiveNeuronal differentiationSuperparamagnetic iron oxide nanoparticlesTherapeutic strategyStem cells
Targeted stem cell delivery with microrobots has emerged as a potential alternative therapeutic strategy in regenerative medicine, and intranasal administration is an effective approach for minimally invasive delivery of therapeutic agents into the brain. In this study, a magnetically powered stem cell-based microrobot (“Cellbot”) is used for minimally invasive targeted stem cell delivery to the brain through the intranasal passage. The Cellbot is developed by internalizing superparamagnetic iron oxide nanoparticles (SPIONs) into human nasal turbinate stem cells. The SPIONs have no influence on hNTSC characteristics, including morphology, cell viability, and neuronal differentiation. The Cellbots are capable of proliferation and differentiation into neurons, neural precursor cells, and neurogliocytes. The Cellbots in the microfluidic channel can be reliably manipulated by an external magnetic field for orientation and position control. Using an ex vivo model based on brain organoids, it is determined that the Cellbots can be transplanted into brain tissue. Using a murine model, it is demonstrated that the Cellbots can be intranasally administered and magnetically guided to the target tissue in vivo. This approach has the potential to effectively treat central nervous system disorders in a minimally invasive manner. © 2021 Wiley-VCH GmbH
John Wiley and Sons Ltd
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Department of Robotics and Mechatronics EngineeringBio-Micro Robotics Lab1. Journal Articles

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