Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 유성운 | - |
| dc.contributor.author | Youngchae Lee | - |
| dc.date.accessioned | 2022-03-07T16:00:36Z | - |
| dc.date.available | 2022-03-07T16:00:36Z | - |
| dc.date.issued | 2022 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000593750 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/16319 | - |
| dc.description | Autophagic cell death (ACD), Apoptosis, Corticosterone (CORT), Hippocampal neural stem (HCN) cells, Casein kinase 2 (CK2), Psychological stress. | - |
| dc.description.statementofresponsibility | N | - |
| dc.description.tableofcontents | Ⅰ. Introduction 1 Ⅱ. Material and Methods 3 2.1 Reagents and antibodies 3 2.2 Animals 3 2.3 Cell culture 4 2.4 Transfection 4 2.5 Immunocytochemistry 4 2.6 Cell death assay 5 2.7 Generation of stable knockdown HCN cells 5 2.8 Western blotting analysis 5 2.9 Statistical analysis 6 Ⅲ. Results 8 3.1 CORT induces ACD, not apoptosis in HCN cells 8 3.2 CK2 inhibition further increases CORT-induced death in HCN cells 12 3.3 Knockdown of CK2α subunit switches ACD to apoptosis 14 3.4 Knockdown of CK2β subunit switches ACD to apoptosis 17 3.5 Generation of NSC-specific, inducible CK2β cKO mice 20 Ⅳ. Discussion 24 Ⅴ. Reference 26 Abstract in Korean 30 |
- |
| dc.format.extent | 30 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.subject | Autophagic cell death (ACD), Apoptosis, Corticosterone (CORT), Hippocampal neural stem (HCN) cells, Casein kinase 2 (CK2), Psychological stress. | - |
| dc.title | Role of CK2 in autophagic cell death following corticosterone treatment in adult hippocampal neural stem cells | - |
| dc.title.alternative | 성체 해마신경줄기세포의 코르티코스테론 유도 오토파지 세포사멸에서의 CK2의 역할 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/thesis.200000593750 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Brain and Cognitive Sciences | - |
| dc.contributor.coadvisor | Byung-Hoon Lee | - |
| dc.date.awarded | 2022/02 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BM 이64 202202 | - |
| dc.date.accepted | 1/21/22 | - |
| dc.contributor.alternativeDepartment | 뇌인지과학전공 | - |
| dc.embargo.liftdate | 20270228 | - |
| dc.contributor.affiliatedAuthor | Youngchae Lee | - |
| dc.contributor.affiliatedAuthor | Seong-Woon Yu | - |
| dc.contributor.affiliatedAuthor | Byung-Hoon Lee | - |
| dc.contributor.alternativeName | 이영채 | - |
| dc.contributor.alternativeName | Seong-Woon Yu | - |
| dc.contributor.alternativeName | 이병훈 | - |
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