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dc.contributor.advisor 유성운 -
dc.contributor.author Youngchae Lee -
dc.date.accessioned 2022-03-07T16:00:36Z -
dc.date.available 2022-03-07T16:00:36Z -
dc.date.issued 2022 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200000593750 en_US
dc.identifier.uri http://hdl.handle.net/20.500.11750/16319 -
dc.description Autophagic cell death (ACD), Apoptosis, Corticosterone (CORT), Hippocampal neural stem (HCN) cells, Casein kinase 2 (CK2), Psychological stress. -
dc.description.statementofresponsibility N -
dc.description.tableofcontents Ⅰ. Introduction 1
Ⅱ. Material and Methods 3
2.1 Reagents and antibodies 3
2.2 Animals 3
2.3 Cell culture 4
2.4 Transfection 4
2.5 Immunocytochemistry 4
2.6 Cell death assay 5
2.7 Generation of stable knockdown HCN cells 5
2.8 Western blotting analysis 5
2.9 Statistical analysis 6
Ⅲ. Results 8
3.1 CORT induces ACD, not apoptosis in HCN cells 8
3.2 CK2 inhibition further increases CORT-induced death in HCN cells 12
3.3 Knockdown of CK2α subunit switches ACD to apoptosis 14
3.4 Knockdown of CK2β subunit switches ACD to apoptosis 17
3.5 Generation of NSC-specific, inducible CK2β cKO mice 20
Ⅳ. Discussion 24
Ⅴ. Reference 26
Abstract in Korean 30
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dc.format.extent 30 -
dc.language eng -
dc.publisher DGIST -
dc.subject Autophagic cell death (ACD), Apoptosis, Corticosterone (CORT), Hippocampal neural stem (HCN) cells, Casein kinase 2 (CK2), Psychological stress. -
dc.title Role of CK2 in autophagic cell death following corticosterone treatment in adult hippocampal neural stem cells -
dc.title.alternative 성체 해마신경줄기세포의 코르티코스테론 유도 오토파지 세포사멸에서의 CK2의 역할 -
dc.type Thesis -
dc.identifier.doi 10.22677/thesis.200000593750 -
dc.description.degree Master -
dc.contributor.department Brain and Cognitive Sciences -
dc.contributor.coadvisor Byung-Hoon Lee -
dc.date.awarded 2022/02 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.BM 이64 202202 -
dc.date.accepted 1/21/22 -
dc.contributor.alternativeDepartment 뇌인지과학전공 -
dc.embargo.liftdate 20270228 -
dc.contributor.affiliatedAuthor Youngchae Lee -
dc.contributor.affiliatedAuthor Seong-Woon Yu -
dc.contributor.affiliatedAuthor Byung-Hoon Lee -
dc.contributor.alternativeName 이영채 -
dc.contributor.alternativeName Seong-Woon Yu -
dc.contributor.alternativeName 이병훈 -
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