Cited 0 time in webofscience Cited 11 time in scopus

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans
Seo, M[Seo, Mihwa]Seo, K[Seo, Keunhee]Hwang, W[Hwang, Wooseon]Koo, HJ[Koo, Hee Jung]Hahm, JH[Hahm, Jeong-Hoon]Yang, JS[Yang, Jae-Seong]Han, SK[Han, Seong Kyu]Hwang, D[Hwang, Daehee]Kim, S[Kim, Sanguk]Jang, SK[Jang, Sung Key]Lee, Y[Lee, Yoontae]Nam, HG[Nam, Hong Gil]Lee, SJV[Lee, Seung-Jae V.]
DGIST Authors
Hwang, D[Hwang, Daehee]Nam, HG[Nam, Hong Gil]
Issue Date
Proceedings of the National Academy of Sciences of the United States of America, 112(31), E4246-E4255
Article Type
AgingAnimalAnimalsBase SequenceC. ElegansCaenorhabditis ElegansCaenorhabditis Elegans ProteinCaenorhabditis Elegans ProteinsControlled StudyDAF-16 Protein, C. ElegansDAF-2 Protein, C. ElegansDead Box ProteinEnzymologyForkhead Transcription FactorForkhead Transcription FactorsFOXOGeneGene Expression ProfilingGene Expression RegulationGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGene OntologyGene SilencingGenes, HelminthGeneticsHeat StressHel-1 Protein, C. ElegansHelicase 1InsulinInsulin-Like Growth Factor IInsulin ReceptorInsulin/IGF-1IntestineIntestinesLifespanLongevityMammaliaMessenger RNAMetabolismMitochondrial RespirationMolecular GeneticsMolecular Sequence DataMutationNerve CellNeuronsNon-HumanNucleotide SequenceOxidative StressPhenotypePhysiologyPriority JournalProgenyProtein BindingPseudomonas AeruginosaReceptor, InsulinRegulatory MechanismReproductionRNA HelicaseRNA HelicasesRNA InterferenceRNA SequenceRNA, MessengerSequence AnalysisSequence Analysis, RNASignal TransductionSomatomedinSomatomedin 1Somatomedin CTranscription Factor Daf16Transcription Factor FOXOTransgeneUnclassified DrugUp-RegulationUpregulation
The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in aging has not been explored. Here, we report that a large fraction of RNA helicases regulate the lifespan of Caenorhabditis elegans. In particular, we show that a DEAD-box RNA helicase, helicase 1 (HEL-1), promotes longevity by specifically activating the DAF-16/forkhead box O (FOXO) transcription factor signaling pathway. We find that HEL-1 is required for the longevity conferred by reduced insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) and is sufficient for extending lifespan. We further show that the expression of HEL-1 in the intestine and neurons contributes to longevity. HEL-1 enhances the induction of a large fraction of DAF-16 target genes. Thus, the RNA helicase HEL-1 appears to promote longevity in response to decreased IIS as a transcription coregulator of DAF-16. Because HEL-1 and IIS are evolutionarily well conserved, a similar mechanism for longevity regulation via an RNA helicase-dependent regulation of FOXO signaling may operate in mammals, including humans.
National Academy of Sciences
Related Researcher
  • Author Hwang, Daehee Systems Biology and Medicine Lab
  • Research Interests Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
There are no files associated with this item.
Department of New BiologySystems Biology and Medicine Lab1. Journal Articles
Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles

qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.