Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 엄지원 | - |
| dc.contributor.author | Hyeji Jung | - |
| dc.date.accessioned | 2022-07-07T02:29:13Z | - |
| dc.date.available | 2022-07-07T02:29:13Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000364357 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/16692 | - |
| dc.description.statementofresponsibility | N | - |
| dc.description.tableofcontents | I. Introduction 1 1.1 E/I balance in neural network 1 1.2 Inhibitory synaptic structure and organizers 2 1.3 Functional role of IQSEC3 3 Ⅱ. Materials and methods 5 2.1 Animals 5 2.2 Stereotactic virus injection 5 2.3 Immunohistochemistry 6 2.4 Seizure test 6 2.5 LABORAS home cage activity analysis 6 2.6 Behavioral tests 7 2.7 Drug administration 9 III. Results 10 3.1 Generation of Iqsec3 conditional knockout (cKO) mice 10 3.2 Decreased GABAergic synapses in hippocampal CA1 of Nestin-Iqsec3 mice 10 3.3 Selective reduction in symmetric synaptic structures in hippocampal CA1 of Nestin-Iqsec3 mice 11 3.4 Increased seizure susceptibility of Nestin-Iqsec3 mice 11 3.5 Impaired spatial memory of Nestin-Iqsec3 mice 12 3.6 No alterations in home cage activities of Nestin-Iqsec3 mice 12 3.7 No alterations in anxiety-related behaviors of Nestin-Iqsec3 mice 12 3.8 No alterations in memories and social behaviors of Nestin-Iqsec3 mice 12 3.9 Decreased depressive-like behaviors of Nestin-Iqsec3 mice 13 3.10 Antidepressive-like behaviors of Nestin-Iqsec3 mice responded to valproic acid but not to rapamycin 13 3.11 No alteration in depressive-like behaviors of mice with Iqsec3 deletion in SST-IN 14 3.12 Reduction in GABAergic synapses in mPFC of Nestin-Iqsec3 mice 14 3.13 mPFC-specific Iqsec3 KO mice recapitulated antidepressive-like behavior 15 Ⅳ. Discussion 30 V. Reference 32 Ⅵ. 요 약 문 35 |
- |
| dc.format.extent | 35 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.subject | IQSEC3, spatial memory, Depression, GABAergic synapse, IQSEC3, 공간 기억, 우울증, GABA 성 시냅스 | - |
| dc.title | Investigation of IQSEC3 functions in regulating GABAergic synapse development and depression-like behavior in mice | - |
| dc.title.alternative | 억제성 시냅스 발달과 공간 기억력 조절하는 IQSEC3의 역할 규명 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/thesis.200000364357 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Brain and Cognitive Sciences | - |
| dc.contributor.coadvisor | Jinsoo Seo | - |
| dc.date.awarded | 2021/02 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BM 정94 202102 | - |
| dc.contributor.alternativeDepartment | 뇌인지과학전공 | - |
| dc.embargo.liftdate | 2026-02-28 | - |
| dc.contributor.affiliatedAuthor | Hyeji Jung | - |
| dc.contributor.affiliatedAuthor | Ji Won Um | - |
| dc.contributor.affiliatedAuthor | Jinsoo Seo | - |
| dc.contributor.alternativeName | 정혜지 | - |
| dc.contributor.alternativeName | Ji Won Um | - |
| dc.contributor.alternativeName | 서진수 | - |
- Files in This Item:
-
There are no files associated with this item.
- Appears in Collections:
- Department of Brain Sciences Theses Master
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.