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Optogenetic Neural Interface for Non-Human Primates

Title
Optogenetic Neural Interface for Non-Human Primates
Translated Title
영장류를 위한 광유전학 신경 인터페이스
Authors
Saehyuck Oh
DGIST Authors
Saehyuck Oh; Kyung-In Jang; Jae-Woong Jeong
Advisor(s)
장경인
Co-Advisor(s)
Jae-Woong Jeong
Issue Date
2021
Available Date
2022-07-07
Degree Date
2021/02
Type
Thesis
Keywords
Non-human primates, optogenetics, wireless, neural interface, 영장류, 광유전학, 무선 통신, 신경 인터페이스
Abstract
The non-human primate brain, which is similar to the human brain, plays a critical role in understanding of human brain circuits related to incurable diseases. Among the methods for studying the brain, optogenetics is widely used as a powerful way to reveal brain circuits by genetically coding certain parts of the brain and simultaneously performing optical brain stimulation and neural signal measurement. Although primate optogenetics in a free-moving state is important for complex brain related behavioral research, most of them were performed only under anesthesia due to engineering difficulties such as probe insertion method, full device implantation, wireless communication. To overcome the challenges, we fabricated a sucrose-coated long length flexible neural probe for insertion into the deep brain area with minimal invasion and also applied an optimized wireless communication protocol for fully implant operation. Finally, we developed a fully implantable wireless optogenetic neural in-terface for advanced research application such as behavior, cognition and emotional research in free-moving primates. Our integrated device shows the potential to research the control of higher behaviors leading to feeding behavior by regulating the LHA of primate's brain.
Table Of Contents
I. Introduction II. Backgrounds 2.1 Need for Brain Research 2.2 Brain Engineering : Chemical approach, Electrical approach 2.3 Closed-loop Control of Brain Engineering 2.4 Recent Research of Brain Engineering III. Materials and Methods 3.1 Concept of Wireless Optogenetic Neural Interface 3.2 Fabrication of Neural Probe 3.3 Sucrose Coating for Insertion into Deep Brain Area 3.4 Circuit Diagram of Wireless Neural Interface 3.5 System protocol of Firmware IV. Results and Discussion 4.1 Electrochemical Impedance Measurement of Neural Probe 4.2 Device Function : Frequency, Duty Variability 4.3 In-vitro Test for Verification of Device Performance 4.4 In-vivo Test : Mouse 4.5 In-vivo Test : Primate V. Conclusion VI. References 요 약 문
URI
http://dgist.dcollection.net/common/orgView/200000364405
http://hdl.handle.net/20.500.11750/16693
DOI
10.22677/thesis.200000364405
Degree
Master
Department
Robotics Engineering
University
DGIST
Related Researcher
  • Author Jang, Kyung-In Bio-integrated Electronics Lab
  • Research Interests Extreme mechanics; Stand-alone electronics; Heterogeneous materials; Biocompatible interfaces
Files:
Collection:
Department of Robotics and Mechatronics EngineeringThesesMaster


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