Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Gwon, Kihak | - |
dc.contributor.author | Park, Jong-Deok | - |
dc.contributor.author | Lee, Seonhwa | - |
dc.contributor.author | Choi, Won Il | - |
dc.contributor.author | Hwang, Youngmin | - |
dc.contributor.author | Mori, Munemasa | - |
dc.contributor.author | Yu, Jong-Sung | - |
dc.contributor.author | Lee, Do Nam | - |
dc.date.accessioned | 2022-09-06T08:00:02Z | - |
dc.date.available | 2022-09-06T08:00:02Z | - |
dc.date.created | 2022-04-06 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/16855 | - |
dc.description.abstract | Bacterial infections have become a severe threat to human health and antibiotics have been developed to treat them. However, extensive use of antibiotics has led to multidrug-resistant bacteria and reduction of their therapeutic effects. An efficient solution may be localized application of antibiotics using a drug delivery system. For clinical application, they need to be biodegradable and should offer a prolonged antibacterial effect. In this study, a new injectable and visible-light-crosslinked hyaluronic acid (HA) hydrogel loaded with silicon (Si)-based nickel oxide (NiO) nanoflowers (Si@NiO) as an antibacterial scaffold was developed. Si@NiO nanoflowers were synthesized using chemical bath deposition before encapsulating them in the HA hydrogel under a mild visible-light-crosslinking conditions to generate a Si@NiO-hydrogel. Si@NiO synthesis was confirmed using scanning electron microscopy, transmission electron microscopy, and powder X-ray diffraction. As-prepared Si@NiO-hydrogel exhibited enhanced mechanical properties compared to a control bare hydrogel sample. Moreover, Si@NiO-hydrogel exhibits excellent antibacterial properties against three bacterial strains (P. aeruginosa, K. pneumoniae, and methicillin-resistant Staphylococcus aureus (>99.9% bactericidal rate)) and negligible cytotoxicity toward mouse embryonic fibroblasts. Therefore, Si@NiO-hydrogel has the potential for use in tissue engineering and biomedical applications owing to its injectability, visible-light crosslink ability, degradability, biosafety, and superior antibacterial property. © 2022 | - |
dc.language | English | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Injectable hyaluronic acid hydrogel encapsulated with Si-based NiO nanoflower by visible light cross-linking: Its antibacterial applications | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2022.03.051 | - |
dc.identifier.wosid | 000855592900001 | - |
dc.identifier.scopusid | 2-s2.0-85126544444 | - |
dc.identifier.bibliographicCitation | International Journal of Biological Macromolecules, v.208, pp.149 - 158 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | Antibacterial nanoflower | - |
dc.subject.keywordAuthor | Biodegradable polymer | - |
dc.subject.keywordAuthor | Photocrosslinking hydrogel | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | OXIDE | - |
dc.subject.keywordPlus | PHOTOPOLYMERIZATION | - |
dc.subject.keywordPlus | CYTOCOMPATIBILITY | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | ADHESIVE | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | SILICON | - |
dc.citation.endPage | 158 | - |
dc.citation.startPage | 149 | - |
dc.citation.title | International Journal of Biological Macromolecules | - |
dc.citation.volume | 208 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Chemistry; Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science | - |
dc.type.docType | Article | - |
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