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Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy

Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy
Intisar, Aseer TasnufShin, Hyun YoungKim, Woon-HaeKang, Hyun GyuKim, Min. Young.Kim, Yu SeonCho, YoungjunMo, Yun JeoungLim, HeejinLee, SanghoonLu, Q. RichardLee, Yun-IlKim, Minseok S.
Issued Date
Advanced Science, v.9, no.32
Author Keywords
Charcot-Marie-Tooth diseasecholesterolelectroceuticalsmyelinationmyelin membrane integrityperipheral demyelinating neuropathiesPMP22
Although many efforts are undertaken to treat peripheral demyelinating neuropathies based on biochemical interventions, unfortunately, there is no approved treatment yet. Furthermore, previous studies have not shown improvement of the myelin membrane at the biomolecular level. Here, an electroceutical treatment is introduced as a biophysical intervention to treat Charcot-Marie-Tooth (CMT) disease-the most prevalent peripheral demyelinating neuropathy worldwide-using a mouse model. The specific electrical stimulation (ES) condition (50 mV mm(-1), 20 Hz, 1 h) for optimal myelination is found via an in vitro ES screening system, and its promyelinating effect is validated with ex vivo dorsal root ganglion model. Biomolecular investigation via time-of-flight secondary ion mass spectrometry shows that ES ameliorates distribution abnormalities of peripheral myelin protein 22 and cholesterol in the myelin membrane, revealing the restoration of myelin membrane integrity. ES intervention in vivo via flexible implantable electrodes shows not only gradual rehabilitation of mouse behavioral phenotypes (balance and endurance), but also restored myelin thickness, compactness, and membrane integrity. This study demonstrates, for the first time, that an electroceutical approach with the optimal ES condition has the potential to treat CMT disease and restore impaired myelin membrane integrity, shifting the paradigm toward practical interventions for peripheral demyelinating neuropathies.
Wiley-VCH Verlag
Related Researcher
  • 이상훈 Lee, Sanghoon 로봇및기계전자공학과
  • Research Interests Neural interface; Neuroprosthetics; Bioelectronics; Robotics
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Appears in Collections:
Department of New Biology ETC 1. Journal Articles
Division of Biotechnology 1. Journal Articles
Department of Robotics and Mechatronics Engineering Neuro-Interfaced Robotics Lab 1. Journal Articles
Department of New Biology BioDr. Lab - Nanobiomedicine 1. Journal Articles


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