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dc.contributor.author Baek, Seung-Hoon -
dc.contributor.author Noh, Ah Reum -
dc.contributor.author Kim, Kyeong-A. -
dc.contributor.author Akram, Muhammad -
dc.contributor.author Shin, Young-Jun -
dc.contributor.author Kim, Eun-Sun -
dc.contributor.author Yu, Seong Woon -
dc.contributor.author Majid, Arshad -
dc.contributor.author Bae, Ok-Nam -
dc.date.available 2017-07-11T06:20:06Z -
dc.date.created 2017-04-10 -
dc.date.issued 2014-08 -
dc.identifier.issn 0039-2499 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/3063 -
dc.description.abstract BACKGROUND AND PURPOSE - : Despite the rapidly increasing global burden of ischemic stroke, no therapeutic options for neuroprotection against stroke currently exist. Recent studies have shown that autophagy plays a key role in ischemic neuronal death, and treatments that target autophagy may represent a novel strategy in neuroprotection. We investigated whether autophagy is regulated by carnosine, an endogenous pleiotropic dipeptide that has robust neuroprotective activity against ischemic brain damage. METHODS - : We examined the effect of carnosine on mitochondrial dysfunction and autophagic processes in rat focal ischemia and in neuronal cultures. RESULTS - : Autophagic pathways such as reduction of phosphorylated mammalian target of rapamycin (mTOR)/p70S6K and the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II were enhanced in the ischemic brain. However, treatment with carnosine significantly attenuated autophagic signaling in the ischemic brain, with improvement of brain mitochondrial function and mitophagy signaling. The protective effect of carnosine against autophagy was also confirmed in primary cortical neurons. CONCLUSIONS - : Taken together, our data suggest that the neuroprotective effect of carnosine is at least partially mediated by mitochondrial protection and attenuation of deleterious autophagic processes. Our findings shed new light on the mechanistic pathways that this exciting neuroprotective agent influences. © 2014 American Heart Association, Inc. -
dc.publisher Lippincott Williams and Wilkins -
dc.title Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage -
dc.type Article -
dc.identifier.doi 10.1161/STROKEAHA.114.005183 -
dc.identifier.scopusid 2-s2.0-84905398294 -
dc.identifier.bibliographicCitation Stroke, v.45, no.8, pp.2438 - 2443 -
dc.subject.keywordAuthor autophagy -
dc.subject.keywordAuthor carnosine -
dc.subject.keywordAuthor mitochondria -
dc.subject.keywordPlus FOCAL CEREBRAL-ISCHEMIA -
dc.subject.keywordPlus NEURONAL CELL-DEATH -
dc.subject.keywordPlus DOUBLE-EDGED-SWORD -
dc.subject.keywordPlus INFARCT VOLUME -
dc.subject.keywordPlus RAT MODEL -
dc.subject.keywordPlus STROKE -
dc.subject.keywordPlus INJURY -
dc.subject.keywordPlus DISEASE -
dc.subject.keywordPlus MICE -
dc.subject.keywordPlus MITOPHAGY -
dc.citation.endPage 2443 -
dc.citation.number 8 -
dc.citation.startPage 2438 -
dc.citation.title Stroke -
dc.citation.volume 45 -
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Department of Brain Sciences Laboratory of Neuronal Cell Death 1. Journal Articles

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