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AMP-activated protein kinase as a key molecular link between metabolism and clockwork

AMP-activated protein kinase as a key molecular link between metabolism and clockwork
Lee, YongjinKim, Eun-Kyoung
DGIST Authors
Kim, Eun-Kyoung
Issue Date
Experimental and Molecular Medicine, 45
Article Type
5 Amino 4 Imidazolecarboxamide RibosideAMP-Activated Protein KinasesAMPKAnimalAnimalsBMAL1 GeneCasein Kinase ICircadian ClockCircadian ClocksCircadian RhythmCKIClock GeneCRYCry1 GeneCry2 GeneCryptochromeCryptochrome 1Cryptochrome 2CryptochromesEnergy BalanceEnzyme ActivationEnzyme PhosphorylationFeedback SystemGeneGene Expression RegulationHumanHumansHydroxymethylglutaryl Coenzyme A Reductase KinaseIntracellular SignalingMetabolic DisorderMetabolic RegulationMetabolismMetforminMolecular ClockMolecular InteractionMolecular SensorNeuromodulationNicotinamide Adenine DinucleotideNon-HumanNon-Insulin Dependent Diabetes MellitusPalmitic AcidPER1 GenePER1 ProteinPER2 GenePER2 ProteinProtein BMAL1Protein DegradationProtein FunctionProtein ProcessingReviewSIRT1SirtuinSirtuin1SirtuinsTranscription Factor Clock
Circadian clocks regulate behavioral, physiological and biochemical processes in a day/night cycle. Circadian oscillators have an essential role in the coordination of physiological processes with the cyclic changes in the physical environment. Such mammalian circadian clocks composed of the positive components (BMAL1 and CLOCK) and the negative components (CRY and PERIOD (PER)) are regulated by a negative transcriptional feedback loop in which PER is rate-limiting for feedback inhibition. In addition, posttranslational modification of these components is critical for setting or resetting the circadian oscillation. Circadian regulation of metabolism is mediated through reciprocal signaling between the clock and metabolic regulatory networks. AMP-activated protein kinase (AMPK) in the brain and peripheral tissue is a crucial cellular energy sensor that has a role in metabolic control. AMPK-mediated phosphorylation of CRY and Casein kinases I regulates the negative feedback control of circadian clock by proteolytic degradation. AMPK can also modulate the circadian rhythms through nicotinamide adenine dinucleotide- dependent regulation of silent information regulator 1. Growing evidence elucidates the AMPK-mediated controls of circadian clock in metabolic diseases such as obesity and diabetes. In this review, we summarize the current comprehension of AMPK-mediated regulation of the circadian rhythms. This will provide insight into understanding how their components regulate the metabolism. © 2013 KSBMB.
Nature Publishing Group
Related Researcher
  • Author Kim, Eun-Kyoung Lab of Neuro-Metabolism & Neurometabolomic Research Center
  • Research Interests Neural functions in metabolic diseases; 뇌신경세포와 비만; 당뇨 등의 대사 질환 관련 연구
Department of Brain and Cognitive SciencesLab of Neuro-Metabolism & Neurometabolomic Research Center1. Journal Articles

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