Cited time in webofscience Cited time in scopus

Neuromodulatory State and Sex Specify Alternative Behaviors through Antagonistic Synaptic Pathways in C. elegans

Neuromodulatory State and Sex Specify Alternative Behaviors through Antagonistic Synaptic Pathways in C. elegans
Jang, HeeunKim, Kyu HyungNeal, Scott J.Macosko, EvanKim, DongshinButcher, Rebecca A.Zeiger, Danna M.Bargmann, Cornelia I.Sengupta, Piali
DGIST Authors
Kim, Kyu Hyung
Issued Date
Article Type
Adaptive BehaviorAnalysis of VarianceAnimalsAnimals, Genetically ModifiedAscarosideCaenorhabditis ElegansCaenorhabditis Elegans ProteinsCalciumComplement C9Controlled StudyCrossover ProcedureDose-Response Relationship, DrugDrug InteractionsEscape ReactionFemaleGap JunctionGreen Fluorescent ProteinsImmunologic FactorsLuminescent ProteinsMaleMutationNerve Cell NetworkNerve NetNerve Tissue ProteinsNeural PathwaysNeuromodulationNeuronsNeurotransmitter AgentsNon-HumanPheromonePheromonesPriority JournalReaction TimeReceptors, Neuropeptide YReceptors, OdorantSensory Nerve CellSensory StimulationSex CharacteristicsSex DifferenceSignal TransductionSynapsesSynaptic TransmissionTransient Receptor Potential ChannelsUnclassified Drug
Pheromone responses are highly context dependent. For example, the C. elegans pheromone ascaroside C9 (ascr#3) is repulsive to wild-type hermaphrodites, attractive to wild-type males, and usually neutral to "social" hermaphrodites with reduced activity of the npr-1 neuropeptide receptor gene. We show here that these distinct behavioral responses arise from overlapping push-pull circuits driven by two classes of pheromone-sensing neurons. The ADL sensory neurons detect C9 and, in wild-type hermaphrodites, drive C9 repulsion through their chemical synapses. In npr-1 mutant hermaphrodites, C9 repulsion is reduced by the recruitment of a gap junction circuit that antagonizes ADL chemical synapses. In males, ADL sensory responses are diminished; in addition, a second pheromone-sensing neuron, ASK, antagonizes C9 repulsion. The additive effects of these antagonistic circuit elements generate attractive, repulsive, or neutral pheromone responses. Neuronal modulation by circuit state and sex, and flexibility in synaptic output pathways, may permit small circuits to maximize their adaptive behavioral outputs. © 2012 Elsevier Inc.
Cell Press
Related Researcher
  • 김규형 Kim, Kyuhyung 뇌과학과
  • Research Interests Neurobehavior; Neural Circuit; Neurodevelopment; 신경회로; 신경행동; 신경발생; 신경유전학
Files in This Item:

There are no files associated with this item.

Appears in Collections:
Department of Brain Sciences The K. Kim Lab of Neurobehavior and Neural Circuits 1. Journal Articles


  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.