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Implications of Circadian Rhythm in Dopamine and Mood Regulation

Implications of Circadian Rhythm in Dopamine and Mood Regulation
Kim, Jeong-AhJang, Sang WonChoe, Han KyoungChung, Soo-YoungSon, Gi-HoonKim, Kyung Jin
DGIST Authors
Jang, Sang Won; Choe, Han Kyoung
Issue Date
Molecules and Cells, 40(7), 450-456
Article Type
BrainCircadian RhythmClock GeneDiseaseDopaminergic SystemGene-ExpressionMood DisorderNonmotor SymptomsParkinson’s DiseaseParkinson&apossParkinsons-DiseaseREV-ERB alphaRev-Erb-AlphaREV-ERBαRewardSubstantia-NigraSuprachiasmatic NucleusVentral Tegmental Area
Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-erbα induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion- related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson’s disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction. © The Korean Society for Molecular and Cellular Biology. All rights reserved.
Korean Society for Molecular and Cellular Biology
Related Researcher
  • Author Choe, Han Kyoung CHOE LAB: Animal Behavior and Circadian rhythm
  • Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
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Department of Brain and Cognitive SciencesCHOE LAB: Animal Behavior and Circadian rhythm1. Journal Articles

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