Title

Dysregulation of mossy cell by early life stress and its implication in cognitive deficit in adults

DGIST Authors

Mina Kang ; Yong-Seok Oh ; Hyosang Lee

Advisor

오용석

Co-Advisor(s)

Hyosang Lee

Issued Date

2023

Awarded Date

2023-08-01

Citation

Mina Kang. (2023). Dysregulation of mossy cell by early life stress and its implication in cognitive deficit in adults. doi: 10.22677/THESIS.200000686982

Type

Thesis

Description

Early life stress; Cognitive; Hippocampus; Mossy cell; Pattern separation; Context discrimination

Table Of Contents

Abstract i
List of contents ii
Ⅰ. Introduction 1
ⅠⅠ. Method 5
2.1 Animal 5
2.2 Early life stress 5
2.3 Behavior test 5
2.3.1 Open field test 6
2.3.2 Light dark box 6
2.3.3 Elevated plus maze 6
2.3.4 Novelty suppressed feeding 6
2.3.5 Tail suspension test 7
2.3.6 Pattern separation 7
2.4 Stereotaxic surgery 8
2.5 Immunohistochemistry 8
2.6 Fluorescence imaging 9
2.7 Statistics 9
ⅠⅠⅠ. Result 10
3.1 Early life stress model with limited bedding and behavior validation. 10
3.2 ELS affects mild anxiety-like behavior, particularly LD box test in adults. 10
3.3 ELS had no effect on the number of MCs. 11
3.4 ELS had no effect on the exonal projection pattern of MCs. 11
3.5 ELS suppresses the expression of the MCs neurotransmitter, GluR2/3. 12
3.6 ELS reduced the cell activity of MCs and GCs. 12
3.7 ELS impaired rapid context discrimination. 13
IV. Graphical Summary 31
V. Discussion 32
VI. References 35
VII. Summary in Korean 40

URI

http://hdl.handle.net/20.500.11750/46419
http://dgist.dcollection.net/common/orgView/200000686982

DOI

10.22677/THESIS.200000686982

Degree

Master

Department

Department of Brain Sciences

Publisher

DGIST

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