Dysregulation of mossy cell by early life stress and its implication in cognitive deficit in adults
- Title
- Dysregulation of mossy cell by early life stress and its implication in cognitive deficit in adults
- Author(s)
- Mina Kang
- DGIST Authors
- Mina Kang ; Yong-Seok Oh ; Hyosang Lee
- Advisor
- 오용석
- Co-Advisor(s)
- Hyosang Lee
- Issued Date
- 2023
- Awarded Date
- 2023-08-01
- Type
- Thesis
- Description
- Early life stress; Cognitive; Hippocampus; Mossy cell; Pattern separation; Context discrimination
- Table Of Contents
-
Abstract i
List of contents ii
Ⅰ. Introduction 1
ⅠⅠ. Method 5
2.1 Animal 5
2.2 Early life stress 5
2.3 Behavior test 5
2.3.1 Open field test 6
2.3.2 Light dark box 6
2.3.3 Elevated plus maze 6
2.3.4 Novelty suppressed feeding 6
2.3.5 Tail suspension test 7
2.3.6 Pattern separation 7
2.4 Stereotaxic surgery 8
2.5 Immunohistochemistry 8
2.6 Fluorescence imaging 9
2.7 Statistics 9
ⅠⅠⅠ. Result 10
3.1 Early life stress model with limited bedding and behavior validation. 10
3.2 ELS affects mild anxiety-like behavior, particularly LD box test in adults. 10
3.3 ELS had no effect on the number of MCs. 11
3.4 ELS had no effect on the exonal projection pattern of MCs. 11
3.5 ELS suppresses the expression of the MCs neurotransmitter, GluR2/3. 12
3.6 ELS reduced the cell activity of MCs and GCs. 12
3.7 ELS impaired rapid context discrimination. 13
IV. Graphical Summary 31
V. Discussion 32
VI. References 35
VII. Summary in Korean 40
- URI
-
http://hdl.handle.net/20.500.11750/46419
http://dgist.dcollection.net/common/orgView/200000686982
- Degree
- Master
- Department
- Department of Brain Sciences
- Publisher
- DGIST
- Related Researcher
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Oh, Yong-Seok
- Research Interests Monoaminergic regulation of the CNS and mood;anxiety disorder; 모노아민 (세로토닌; 도파민)에 의한 신경조절과 기분;불안 장애 기전 연구
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- Files in This Item:
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- Appears in Collections:
- Department of Brain Sciences Theses Master
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