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Beneficial effects of silibinin against kainic acidinduced neurotoxicity in the hippocampus in vivo

Title
Beneficial effects of silibinin against kainic acidinduced neurotoxicity in the hippocampus in vivo
Author(s)
Kim, SehwanJung, Un JuOh, Yong-SeokJeon, Min-TaeKim, Hyung-JunShin, Won-HoHong, JungwanKim, Sang Ryong
Issued Date
2017-10
Citation
Experimental Neurobiology, v.26, no.5, pp.266 - 277
Type
Article
Author Keywords
EpilepsyGranule cell dispersionKainic acidNeuroprotectionSilibinin
Keywords
GRANULE CELL DISPERSIONTEMPORAL-LOBE EPILEPSYINDUCED HYPERSENSITIVITY REACTIONSDENTATE GYRUSSIGNALING PATHWAYINFLAMMATORY CYTOKINESOXIDATIVE STRESSCANCER-CELLSMOUSE MODELINHIBITION
ISSN
1226-2560
Abstract
Silibinin, an active constituent of silymarin extracted from milk thistle, has been previously reported to confer protection to the adult brain against neurodegeneration. However, its effects against epileptic seizures have not been examined yet. In order to investigate the effects of silibinin against epileptic seizures, we used a relevant mouse model in which seizures are manifested as status epilepticus, induced by kainic acid (KA) treatment. Silibinin was injected intraperitoneally, starting 1 day before an intrahippocampal KA injection and continued daily until analysis of each experiment. Our results indicated that silibinin-treatment could reduce seizure susceptibility and frequency of spontaneous recurrent seizures (SRS) induced by KA administration, and attenuate granule cell dispersion (GCD), a morphological alteration characteristic of the dentate gyrus (DG) in temporal lobe epilepsy (TLE). Moreover, its treatment significantly reduced the aberrant levels of apoptotic, autophagic and pro-inflammatory molecules induced by KA administration, resulting in neuroprotection in the hippocampus. Thus, these results suggest that silibinin may be a beneficial natural compound for preventing epileptic events. © Experimental Neurobiology 2017.
URI
http://hdl.handle.net/20.500.11750/4756
DOI
10.5607/en.2017.26.5.266
Publisher
Korean Society for Neurodegenerative Disease
Related Researcher
  • 오용석 Oh, Yong-Seok
  • Research Interests Monoaminergic regulation of the CNS and mood;anxiety disorder; 모노아민 (세로토닌; 도파민)에 의한 신경조절과 기분;불안 장애 기전 연구
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Department of Brain Sciences Molecular Psychiatry Lab 1. Journal Articles

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