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Beneficial effects of silibinin against kainic acidinduced neurotoxicity in the hippocampus in vivo

Beneficial effects of silibinin against kainic acidinduced neurotoxicity in the hippocampus in vivo
Kim, S.Jung, U.J.Oh, Yong SeokJeon, M.-T.Kim, Hyung JunShin, W.-H.Hong, J.Kim, S.
DGIST Authors
Oh, Yong Seok
Issue Date
Experimental Neurobiology, 26(5), 266-277
Article Type
Animal CellAnimal ExperimentAnimal ModelAnimal TissueAntiinflammatory ActivityApoptosisArticleAutophagyCaspase 3Cell DeathCell StructureControlled StudyDentate GyrusDisease PredispositionDose ResponseDrug EffectDrug PotencyEpilepsyEpileptic StateFrequencyGranule CellGranule Cell DispersionHippocampusInitiation Factor 4E Binding Protein 1Interleukin 1BetaKainic AcidMaleMammalian Target Of Rapamycin Complex 1MouseNervous System InflammationNeuroprotectionNeurotoxicityNicotinamide Adenine Dinucleotide Adenosine DiphosphateRibosyltransferase 1NonhumanP70 Ribosomal Protein S6 Kinase 1Protein ExpressionProtein PhosphorylationProtein S6SeizureSilibininSpontaneous Recurrent SeizureTemporal Lobe EpilepsyTumor Necrosis FactorUnclassified Drug
Silibinin, an active constituent of silymarin extracted from milk thistle, has been previously reported to confer protection to the adult brain against neurodegeneration. However, its effects against epileptic seizures have not been examined yet. In order to investigate the effects of silibinin against epileptic seizures, we used a relevant mouse model in which seizures are manifested as status epilepticus, induced by kainic acid (KA) treatment. Silibinin was injected intraperitoneally, starting 1 day before an intrahippocampal KA injection and continued daily until analysis of each experiment. Our results indicated that silibinin-treatment could reduce seizure susceptibility and frequency of spontaneous recurrent seizures (SRS) induced by KA administration, and attenuate granule cell dispersion (GCD), a morphological alteration characteristic of the dentate gyrus (DG) in temporal lobe epilepsy (TLE). Moreover, its treatment significantly reduced the aberrant levels of apoptotic, autophagic and pro-inflammatory molecules induced by KA administration, resulting in neuroprotection in the hippocampus. Thus, these results suggest that silibinin may be a beneficial natural compound for preventing epileptic events. © Experimental Neurobiology 2017.
Korean Society for Neurodegenerative Disease
Related Researcher
  • Author Oh, Yong-Seok Laboratory of Neural Signaling Networks
  • Research Interests Monoaminergic regulation of the CNS and mood;anxiety disorder; 모노아민 (세로토닌, 도파민)에 의한 신경조절과 기분;불안 장애 기전 연구
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Department of Brain and Cognitive SciencesLaboratory of Neural Signaling Networks1. Journal Articles

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