Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Gwon, Kihak | - |
dc.contributor.author | Park, Jong-Deok | - |
dc.contributor.author | Lee, Seonhwa | - |
dc.contributor.author | Yu, Jong-Sung | - |
dc.contributor.author | Lee, Do Nam | - |
dc.date.accessioned | 2024-08-30T09:10:14Z | - |
dc.date.available | 2024-08-30T09:10:14Z | - |
dc.date.created | 2024-03-28 | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/56828 | - |
dc.description.abstract | Local antibiotic application might mitigate the burgeoning problem of rapid emergence of antibiotic resistance in pathogenic microbes. To accomplish this, delivery systems must be engineered. Hydrogels have a wide range of physicochemical properties and can mimic the extracellular matrix, rendering them promising materials for local antibacterial agent application. Here, we synthesized antibacterial silicon (Si)-based nickel (Ni) nanoflowers (Si@Ni) and encapsulated them in gelatin methacryloyl (GelMA) using microfluidic and photo-crosslink technology, constructing uniform micro-sized hydrogel spheres (Si@Ni-GelMA). Si@Ni and Si@Ni-GelMA were characterized using X-ray diffraction, transmission electron microscopy, and scanning electron microscopy. Injectable Si@Ni-GelMA exhibited excellent antibacterial activities owing to the antibiotic effect of Ni against Pseudomonas aeruginosa, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus, while showing negligible cytotoxicity. Therefore, the Si@Ni-GelMA system can be used as drug carriers owing to their injectability, visible light-mediated crosslinking, degradation, biosafety, and superior antibacterial properties. © 2024 | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.title | Fabrication of silicon-based nickel nanoflower-encapsulated gelatin microspheres as an active antimicrobial carrier | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2024.130617 | - |
dc.identifier.wosid | 001201184400001 | - |
dc.identifier.scopusid | 2-s2.0-85187203403 | - |
dc.identifier.bibliographicCitation | International Journal of Biological Macromolecules, v.264, no.2 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | Antibacterial nanoflower | - |
dc.subject.keywordAuthor | Photo-crosslinked microsphere | - |
dc.subject.keywordAuthor | Biocompatibility | - |
dc.subject.keywordPlus | MICROPARTICLES | - |
dc.subject.keywordPlus | OXIDE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | ANTIBACTERIAL | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | SPHERES | - |
dc.citation.number | 2 | - |
dc.citation.title | International Journal of Biological Macromolecules | - |
dc.citation.volume | 264 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Chemistry; Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science | - |
dc.type.docType | Article | - |
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