Cited 3 time in webofscience Cited 4 time in scopus

A simple and rapid fabrication method for biodegradable drug-encapsulating microrobots using laser micromachining, and characterization thereof

Title
A simple and rapid fabrication method for biodegradable drug-encapsulating microrobots using laser micromachining, and characterization thereof
Authors
Kim, Jin YoungJeon, Sang HunLee, Ji EunLee, Seung MinLee, Jeong HunJun, Byoung OkJang, Jae EunChoi, Hong Soo
DGIST Authors
Kim, Jin YoungJang, Jae EunChoi, Hong Soo
Issue Date
2018-08
Citation
Sensors and Actuators, B: Chemical, 266, 276-287
Type
Article
Article Type
Article
ISSN
0925-4005
Abstract
Magnetically manipulated biodegradable microrobots that encapsulate drugs from the outset are produced in a novel, simple way using UV-laser micro-machining. This method enables multiple microrobots to be produced rapidly, without the need for post-drug encapsulation or polymerization by light exposure, which may cause the drug compound to denature. The microrobot consists of poly (dl-lactic-co-glycolic acid) (PLGA), iron (Fe) particles and 5-fluorouracil (5-FU) as biodegradable, magnetic and drug material, respectively. The fabricated microrobots are precisely and remotely controlled in a fluidic environment by external magnetic fields. To prove the feasibility of targeted drug delivery, the drug release is profiled as a function of time, biodegrading in aqueous solution at 37 °C over 6 weeks. The Fe concentration has a significant effect on the biodegradation rate of the microrobots. The amount of drug encapsulated can be controlled by adjusting the concentration of the drug in the PLGA/Fe/5-FU mixture whilst fabricating the microrobots. Approximately 0.013 μg of 5-FU is released from a single PLGA/Fe/5-FU microrobot over a period of 6 weeks. In addition, we have conducted drug testing with human colorectal cancer (HCT116) cells to investigate the effect of drugs released from our microrobots on cancer cells. While no significant reduction in live cell ratio was observed with the controls, it decreased approximately 20% when cells were cultured with the PLGA/Fe/5-FU microrobot for 2 days. It presents that 5-FU was delivered from the microrobot to cancer cells and negatively affected them. © 2018 Elsevier B.V.
URI
http://hdl.handle.net/20.500.11750/6204
DOI
10.1016/j.snb.2018.03.033
Publisher
Elsevier B.V.
Related Researcher
  • Author Jang, Jae Eun Advanced Electronic Devices Research Group(AEDRG)
  • Research Interests Nanoelectroinc device; 생체 신호 센싱 시스템 및 생체 모방 디바이스; 나노 통신 디바이스
Files:
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Collection:
DGIST-ETH Microrobotics Research Center1. Journal Articles
Department of Information and Communication EngineeringAdvanced Electronic Devices Research Group(AEDRG)1. Journal Articles
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


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