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  Department of Brain Sciences Laboratory of Aging Brain

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Article
Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4
  • Lee, Se-In ; 
  • Yu, Jichang ; 
  • Lee, Hyein ; 
  • Kim, Buyun ; 
  • Jang, Min Jun ; 
  • Jo, Hyeonbin ; 
  • Kim, Na Yeon ; 
  • Pak, Malk Eun ; 
  • Kim, Jae Kwang ; 
  • Cho, Sukhee ; 
    • et al
  • 2025-08
  • Nature Communications, v.16, no.1
  • Nature Publishing Group
  • View : 31
  • Download : 0
Article
Enhanced differentiation of neural progenitor cells in Alzheimer's disease into vulnerable immature neurons
  • Cho, Joonho ; 
  • Bae, Simsung ; 
  • Jeon, Juyeong ; 
  • Transfeld, Janis ; 
  • Lee, Changyeob ; 
  • Nott, Alexi ; 
  • Gao, Fan ; 
  • Seo, Jinsoo
  • 2025-05
  • Cho, Joonho. (2025-05). Enhanced differentiation of neural progenitor cells in Alzheimer's disease into vulnerable immature neurons. iScience, 28(5). doi: 10.1016/j.isci.2025.112446
  • Cell Press
  • View : 94
  • Download : 0

Imaging lipid rafts reveals the principle of ApoE4-induced AR upregulation in human neurons

Article
Imaging lipid rafts reveals the principle of ApoE4-induced AR upregulation in human neurons
  • Lee, Se-In ; 
  • Lim, Heejin ; 
  • Kim, Na Yeon ; 
  • Yu, Jichang ; 
  • Cho, Joonho ; 
  • Lee, Hyein ; 
  • Moon, Dae Won ; 
  • Seo, Jinsoo
  • 2025-02
  • Lee, Se-In. (2025-02). Imaging lipid rafts reveals the principle of ApoE4-induced AR upregulation in human neurons. iScience, 28(2). doi: 10.1016/j.isci.2025.111893
  • Cell Press
  • View : 111
  • Download : 66
Article
ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells
  • Lee, Jiyeon ; 
  • Lee, Haeryung ; 
  • Lee, Hyein ; 
  • Shin, Miram ; 
  • Shin, Min-Gi ; 
  • Seo, Jinsoo ; 
  • Lee, Eun Jeong ; 
  • Park, Sun Ah ; 
  • Park, Soochul
  • 2023-12
  • Lee, Jiyeon. (2023-12). ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells. Nature Communications, 14(1). doi: 10.1038/s41467-023-44319-3
  • Nature Publishing Group
  • View : 209
  • Download : 37

ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes

Article
ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes
  • Lee, Hyein ; 
  • Cho, Sukhee ; 
  • Kim, Mi-Jin ; 
  • Park, Yeo Jin ; 
  • Cho, Eunji ; 
  • Jo, Yeon Suk ; 
  • Kim, Yong-Seok ; 
  • Lee, Jung Yi ; 
  • Thoudam, Themis ; 
  • Woo, Seung-Hwa ; 
    • et al
  • 2023-10
  • Lee, Hyein. (2023-10). ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes. Cell Reports, 42(10). doi: 10.1016/j.celrep.2023.113183
  • Cell Press
  • View : 340
  • Download : 50

Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer’s disease

Article
Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer’s disease
  • Kim, Mi-Yeon ; 
  • Kim, Mi Jeong ; 
  • Lee, Changyeob ; 
  • Lee, Juwon ; 
  • Kim, Sang Seong ; 
  • Hong, Sungho ; 
  • Kim, Hyoung Tae ; 
  • Seo, Jinsoo ; 
  • Yoon, Ki-Jun ; 
  • Han, Sungho
  • 2023-10
  • Experimental & Molecular Medicine, v.55, no.10, pp.2177 - 2189
  • Springer Nature
  • View : 177
  • Download : 46
Article
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
  • Pao, Ping-Chieh ; 
  • Seo, Jinsoo ; 
  • Lee, Audrey ; 
  • Kritskiy, Oleg ; 
  • Patnaik, Debasis ; 
  • Penney, Jay ; 
  • Raju, Ravikiran M. ; 
  • Geigenmuller, Ute ; 
  • Silva, M. Catarina ; 
  • Lucente, Diane E. ; 
    • et al
  • 2023-04
  • Pao, Ping-Chieh. (2023-04). A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 120(16). doi: 10.1073/pnas.2217864120
  • National Academy of Sciences
  • View : 303
  • Download : 0
Article
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β
  • Park, Jin-Hee ; 
  • Hwang, Jeong-Woo ; 
  • Lee, Hyun-ju ; 
  • Jang, Geum Mi ; 
  • Jeong, Yoo Joo ; 
  • Cho, Joonho ; 
  • Seo, Jinsoo ; 
  • Hoe, Hyang-Sook
  • 2023-06
  • Park, Jin-Hee. (2023-06). Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β. Frontiers in Immunology, 14. doi: 10.3389/fimmu.2023.1150940
  • Frontiers Media
  • View : 255
  • Download : 24
Article
Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
  • Choi, H.-J. ; 
  • Park, J.-H. ; 
  • Jeong, Y.J. ; 
  • Hwang, J.-W. ; 
  • Lee, S. ; 
  • Lee, H. ; 
  • Seol, E. ; 
  • Kim, I.-W. ; 
  • Cha, B.-Y. ; 
  • Seo, J. ; 
    • et al
  • 2022-07
  • Choi, H.-J. (2022-07). Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice. Molecular Brain, 15(1). doi: 10.1186/s13041-022-00948-1
  • BioMed Central
  • View : 236
  • Download : 0

Restoration of Cathepsin D Level via L-Serine Attenuates PPA-Induced Lysosomal Dysfunction in Neuronal Cells

Article
Restoration of Cathepsin D Level via L-Serine Attenuates PPA-Induced Lysosomal Dysfunction in Neuronal Cells
  • Jeon, Hyunbum ; 
  • Kim, Yeo Jin ; 
  • Hwang, Su-Kyeong ; 
  • Seo, Jinsoo ; 
  • Mun, Ji Young
  • 2022-09
  • Jeon, Hyunbum. (2022-09). Restoration of Cathepsin D Level via L-Serine Attenuates PPA-Induced Lysosomal Dysfunction in Neuronal Cells. International Journal of Molecular Sciences, 23(18). doi: 10.3390/ijms231810613
  • MDPI
  • View : 293
  • Download : 24
Article
LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits
  • Kim, Jinhu ; 
  • Park, Dongseok ; 
  • Seo, Na-Young ; 
  • Yoon, Taek Han ; 
  • Kim, Gyu Hyun ; 
  • Lee, Sang-Hoon ; 
  • Seo, Jinsoo ; 
  • Um, Ji Won ; 
  • Lee, Kea Joo ; 
  • Ko, Jaewon
  • 2022-01
  • Kim, Jinhu. (2022-01). LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits. doi: 10.1073/pnas.2110196119
  • National Academy of Sciences
  • View : 861
  • Download : 0

The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons

Article
The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons
  • 2021-11
  • Lee, Davin. (2021-11). The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons. doi: 10.3389/fnmol.2021.756613
  • Frontiers Media S.A.
  • View : 637
  • Download : 165

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

Article
APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation
  • Lee, Se-In ; 
  • Jeong, Woojin ; 
  • Lim, Heejin ; 
  • Cho, Sukhee ; 
  • Lee, Hyein ; 
  • Jang, Yonghee ; 
  • Cho, Joonho ; 
  • Bae, Simsung ; 
  • Lin, Yuan-Ta ; 
  • Tsai, Li-Huei ; 
    • et al
  • 2021-09
  • Lee, Se-In. (2021-09). APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation. Stem Cell Reports, 16(9), 2128–2137. doi: 10.1016/j.stemcr.2021.07.017
  • Cell Press
  • View : 818
  • Download : 65
Article
Neuromyelitis optica (NMO)‐IgG‐driven organelle reorganization in human iPSC‐derived astrocytes
  • Cho, Sukhee ; 
  • Lee, Hyein ; 
  • Jung, Minkyo ; 
  • Hong, Kirim ; 
  • Woo, Seung Hwa ; 
  • Lee, Young-Sam ; 
  • Kim, Byoung Joon ; 
  • Jeon, Mi Young ; 
  • Seo, Jinsoo ; 
  • Mun, Ji Young
  • 2021-10
  • Cho, Sukhee. (2021-10). Neuromyelitis optica (NMO)‐IgG‐driven organelle reorganization in human iPSC‐derived astrocytes. doi: 10.1096/fj.202100637r
  • Federation of American Societies for Experimental Biology
  • View : 608
  • Download : 0

A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids

Article
A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids
  • Park, Jong-Chan ; 
  • Jang, So-Yeong ; 
  • Lee, Dongjoon ; 
  • Lee, Jeongha ; 
  • Kang, Uiryong ; 
  • Chang, Hongjun ; 
  • Kim, Haeng Jun ; 
  • Han, Sun-Ho ; 
  • Seo, Jinsoo ; 
  • Choi, Murim ; 
    • et al
  • 2021-01
  • Park, Jong-Chan. (2021-01). A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids. Nature Communications, 12(1), 280. doi: 10.1038/s41467-020-20440-5
  • Nature Publishing Group
  • View : 597
  • Download : 395
Article
Impact of Genetic Risk Factors for Alzheimer’s Disease on Brain Glucose Metabolism
  • 2021-06
  • Cho, Sukhee. (2021-06). Impact of Genetic Risk Factors for Alzheimer’s Disease on Brain Glucose Metabolism. Molecular Neurobiology, 58(6), 2608–2619. doi: 10.1007/s12035-021-02297-x
  • Springer
  • View : 605
  • Download : 0

Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD

Article
Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD
  • Han, Kyung-Min ; 
  • Kang, Ri Jin ; 
  • Jeon, Hyongjun ; 
  • Lee, Hyun-ju ; 
  • Lee, Ji-Soo ; 
  • Park, HyunHee ; 
  • Jeon, Seong Gak ; 
  • Suk, Kyoungho ; 
  • Seo, Jinsoo ; 
  • Hoe, Hyang-Sook
  • 2020-07
  • Han, Kyung-Min. (2020-07). Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD. doi: 10.3390/cells9071655
  • MDPI AG
  • View : 635
  • Download : 193
Article
C9orf72-Associated Arginine-Rich Dipeptide Repeat Proteins Reduce the Number of Golgi Outposts and Dendritic Branches in Drosophila Neurons
  • 2020-09
  • Park, Jeong Hyang. (2020-09). C9orf72-Associated Arginine-Rich Dipeptide Repeat Proteins Reduce the Number of Golgi Outposts and Dendritic Branches in Drosophila Neurons. doi: 10.14348/molcells.2020.0130
  • 한국분자세포생물학회
  • View : 712
  • Download : 0

Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases

Article
Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases
  • 2020-08
  • Lee, Davin. (2020-08). Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases. doi: 10.1016/j.arr.2020.101069
  • Elsevier BV
  • View : 762
  • Download : 282
Article
ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease
  • Jeong, Woojin ; 
  • Lee, Hyein ; 
  • Cho, Sukhee ; 
  • Seo, Jinsoo
  • 2019-11
  • Jeong, Woojin. (2019-11). ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease. Molecules and Cells, 42(11), 739–746. doi: 10.14348/molcells.2019.0200
  • 한국분자세포생물학회
  • View : 745
  • Download : 0
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