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DC Field Value Language Kim, Keetae ko Choe, Han Kyoung ko 2018-05-25T08:34:30Z - 2018-05-25T08:34:30Z - 2018-05-25 - 2019-01 -
dc.identifier.citation Mechanisms of Ageing and Development, v.177, pp.74 - 79 -
dc.identifier.issn 0047-6374 -
dc.identifier.uri -
dc.description.abstract Aging is characterized by a progressive loss of several physiological functions that can cause various age-related disorders. Several factors have been identified as causes of aging to elucidate the decline in functions. Various aspects of physiological deterioration are controlled by the hypothalamus, a critical brain region that connects the neuroendocrine system to physiological functions. In addition, functional alterations in a set of agouti-related peptide/neuropeptide Y (AgRP/NPY) and pro-opiomelanocortin (POMC) neurons, a set of growth hormone-releasing hormone (GHRH) and somatostatin (SST) neurons, a set of arginine vasopressin (AVP) and vasoactive intestinal peptide (VIP) neurons, and a set of gonadotropin-releasing hormone (GnRH) and kisspeptin/neurokinin B/dynorphin (KNDy) neurons contribute to age-related physiological decline in energy metabolism, hormone regulation, circadian rhythm, and reproduction, respectively. The underlying cellular mechanism for the hypothalamus-mediated aging progression comprises dysregulation of nutrient sensing, altered intercellular communication, stem cell exhaustion, loss of proteostasis, and epigenetic alterations. Furthermore, mammalian target of rapamycin (mTOR), NF-kB, hypothalamic stem cell, autophagy, and SIRT1 have been recognized as critical factors or pathways mediating the mechanism. Perhaps, further dissection of these pathways or components could provide the potential for developing a therapeutic intervention for age-related diseases or the extension of healthy lifespan. © 2018 Elsevier B.V. -
dc.language English -
dc.publisher Elsevier Ireland Ltd -
dc.title Role of hypothalamus in aging and its underlying cellular mechanisms -
dc.type Article -
dc.identifier.doi 10.1016/j.mad.2018.04.008 -
dc.identifier.wosid 000456902900009 -
dc.identifier.scopusid 2-s2.0-85046774500 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.identifier.citationVolume 177 -
dc.identifier.citationStartPage 74 -
dc.identifier.citationEndPage 79 -
dc.identifier.citationTitle Mechanisms of Ageing and Development -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor Aging -
dc.subject.keywordAuthor Hypothalamus -
dc.subject.keywordAuthor Mechanisms -
dc.contributor.affiliatedAuthor Kim, Keetae -
dc.contributor.affiliatedAuthor Choe, Han Kyoung -


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