Cited 6 time in webofscience Cited 8 time in scopus

Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study

Title
Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study
Authors
Ono, YumieEsaki, KimiyaTakahashi, YutaNakabayashi, MikieIchinose, MasashiLee, Kijoon
DGIST Authors
Ono, Yumie; Esaki, Kimiya; Takahashi, Yuta; Nakabayashi, Mikie; Ichinose, Masashi; Lee, Kijoon
Issue Date
2018-09
Citation
Biomedical Optics Express, 9(9), 4539-4551
Type
Article
Article Type
Article
Keywords
POSTOCCLUSIVE REACTIVE HYPEREMIAENDOTHELIAL DYSFUNCTIONVASCULAR-DISEASESKELETAL-MUSCLEDEEP TISSUES
ISSN
2156-7085
Abstract
We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia was highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls. © 2018 Optical Society of America.
URI
http://hdl.handle.net/20.500.11750/9291
DOI
10.1364/BOE.9.004539
Publisher
OSA - The Optical Society
Related Researcher
  • Author Lee, Kijoon Quantum & Biomedical Optics Lab
  • Research Interests Biomedical Optics; DOT; DSCA; NIRS; OCT; LSCI; Nonlinear Optics; Random Laser; Coherent Backscattering
Files:
Collection:
Department of Information and Communication EngineeringQuantum & Biomedical Optics Lab1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE