Cited 1 time in webofscience Cited 3 time in scopus

Magnetically actuated microrobots as a platform for stem cell transplantation

Title
Magnetically actuated microrobots as a platform for stem cell transplantation
Authors
Jeon, SungwoongKim, SangwonHa, ShinwonLee, SeungminKim, EunheeKim, So YeunPark, Sun HwaJeon, Jung HoKim, Sung WonMoon, CheilNelson, Bradley J.Kim, Jin-YoungYu, Seong-WoonChoi, Hongsoo
DGIST Authors
Moon, CheilKim, Jin-YoungYu, Seong-WoonChoi, Hongsoo
Issue Date
2019-05
Citation
Science Robotics, 4(30), eaav4317
Type
Article
Article Type
Article
Keywords
HUMAN INFERIOR TURBINATEBLOOD-VISCOSITYDIFFERENTIATIONTHERAPYFABRICATIONLOCOMOTION
ISSN
2470-9476
Abstract
Magnetic microrobots were developed for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the microrobots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons. Moreover, microrobots were used to transport colorectal carcinoma cancer cells to tumor microtissue in a body-on-a-chip, which comprised an in vitro liver-tumor microorgan network. The microrobots were also controlled in a mouse brain slice and rat brain blood vessel. Last, microrobots carrying mesenchymal stem cells derived from human nose were manipulated inside the intraperitoneal cavity of a nude mouse. The results indicate the potential of microrobots for the culture and delivery of stem cells. Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
URI
http://hdl.handle.net/20.500.11750/9895
DOI
10.1126/scirobotics.aav4317
Publisher
American Association for the Advancement of Science (AAAS)
Related Researcher
  • Author Yu, Seong-Woon Laboratory of Neuronal Cell Death
  • Research Interests Molecular mechanisms of neuronal cell death and neurodegeneration
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles
Department of Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles


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