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Showing results 1 to 31 of 31

Article
A crucial role of ROCK for alleviation of senescence-associated phenotype
  • Park, J.T. ; 
  • Kang, H.T. ; 
  • Park, C.H. ; 
  • Lee, Young Sam ; 
  • Cho, K.A. ; 
  • Park, Sang Chul
  • 2018-06
  • Park, J.T. (2018-06). A crucial role of ROCK for alleviation of senescence-associated phenotype. doi: 10.1016/j.exger.2018.02.012
  • Elsevier BV
  • View : 983
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Article
Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence
  • Park, Joon Tae ; 
  • Lee, Young-Sam ; 
  • Cho, Kyung A. ; 
  • Park, Sang Chul
  • 2018-11
  • Park, Joon Tae. (2018-11). Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence. doi: 10.1016/j.arr.2018.08.003
  • Elsevier Ireland Ltd
  • View : 831
  • Download : 0
Article
Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models
  • Kuk, Myeong Uk ; 
  • Kim, Jae Won ; 
  • Lee, Young-Sam ; 
  • Cho, Kyung A. ; 
  • Park, Joon Tae ; 
  • Park, Sang Chul
  • 2019-03
  • Kuk, Myeong Uk. (2019-03). Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models. doi: 10.14348/molcells.2018.0352
  • 한국분자세포생물학회
  • View : 804
  • Download : 0

ANT2 Accelerates Cutaneous Wound Healing in Aged Skin by Regulating Energy Homeostasis and Inflammation

Article
ANT2 Accelerates Cutaneous Wound Healing in Aged Skin by Regulating Energy Homeostasis and Inflammation
  • Woo, Seung-Hwa ; 
  • Mo, Yun Jeong ; 
  • Lee, Yun-Il ; 
  • Park, Ji Hwan ; 
  • Hwang, Daehee ; 
  • Park, Tae Jun ; 
  • Kang, Hee Young ; 
  • Park, Sang Chul ; 
  • Lee, Young-Sam
  • 2023-11
  • Woo, Seung-Hwa. (2023-11). ANT2 Accelerates Cutaneous Wound Healing in Aged Skin by Regulating Energy Homeostasis and Inflammation. Journal of Investigative Dermatology, 143(11), 2295–2310. doi: 10.1016/j.jid.2023.05.002
  • Elsevier B.V.
  • View : 365
  • Download : 63

Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians

Article
Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians
  • Han, Jungwon ; 
  • Park, So-Hyun ; 
  • Kim, Dong-Jo ; 
  • Kim, Hyori ; 
  • Choi, Yoon-Ho ; 
  • Lee, Jong-Hyuk ; 
  • Park, Sang Chul ; 
  • Chung, Junho
  • 2016-03
  • Immunity and Ageing, v.13, no.1
  • BioMed Central Ltd.
  • View : 543
  • Download : 88
Article
ATM mediated-p53 signaling pathway forms a novel axis for senescence control
  • Hwang, Su Young ; 
  • Kuk, Myeong Uk ; 
  • Kim, Jae Won ; 
  • Lee, Yun Haeng ; 
  • Lee, Young-Sam ; 
  • Choy, Hyon E ; 
  • Park, Sang Chul ; 
  • Park, Joon Tae
  • 2020-11
  • Hwang, Su Young. (2020-11). ATM mediated-p53 signaling pathway forms a novel axis for senescence control. doi: 10.1016/j.mito.2020.09.002
  • Elsevier B.V.
  • View : 594
  • Download : 0
Article
Chemical screening identifies ATM as a target for alleviating senescence
  • Kang, Hyun Tae ; 
  • Park, Joon Tae ; 
  • Choi, Kobong ; 
  • Kim, Yongsub ; 
  • Choi, Hyo Jei Claudia ; 
  • Jung, Chul Won ; 
  • Lee, Young-Sam ; 
  • Park, Sang Chul
  • 2017-06
  • Kang, Hyun Tae. (2017-06). Chemical screening identifies ATM as a target for alleviating senescence. Nature Chemical Biology, 13(6), 616-+. doi: 10.1038/nchembio.2342
  • NATURE PUBLISHING GROUP
  • View : 1157
  • Download : 0
Article
Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome
  • Kang, Hyun Tae ; 
  • Park, Joon Tae ; 
  • Choi, Kobong ; 
  • Choi, Hyo Jei Claudia ; 
  • Jung, Chul Won ; 
  • Kim, Gyu Ree ; 
  • Lee, Young-Sam ; 
  • Park, Sang Chul
  • 2017-06
  • Kang, Hyun Tae. (2017-06). Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome. Aging Cell, 16(3), 541–550. doi: 10.1111/acel.12584
  • WILEY
  • View : 994
  • Download : 0
Conference
Chemical screening identifies ROCK as a target for recoveringmitochondrial function in Hutchinson-Gilford progeria syndrome
  • Kang, Hyun Tae ; 
  • Park, Joon Tae ; 
  • Choi, Kobong ; 
  • Choi, Hyo Jei ; 
  • Jung, Chul Won ; 
  • Kim, Gyu Ree ; 
  • Lee, Young-Sam ; 
  • Park, Sang Chul
  • 2017-06-23
  • Kang, Hyun Tae. (2017-06-23). Chemical screening identifies ROCK as a target for recoveringmitochondrial function in Hutchinson-Gilford progeria syndrome. 2017년 한국노화학회 춘계학술대회.
  • 한국노화학회
  • View : 55
  • Download : 0
Article
Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1
  • Yang, Eun Jae ; 
  • Park, Ji Hwan ; 
  • Cho, Hyun-Ji ; 
  • Hwang, Jeong-A ; 
  • Woo, Seung Hwa ; 
  • Park, Chi Hyun ; 
  • Kim, Sung Young ; 
  • Park, Joon Tae ; 
  • Park, Sang Chul ; 
  • Hwang, Daehee ; 
    • et al
  • 2022-07
  • Yang, Eun Jae. (2022-07). Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1. Communications Biology, 5(1). doi: 10.1038/s42003-022-03658-5
  • Nature Publishing Group
  • View : 541
  • Download : 0
Conference
Controlling Aging Restoration of Cellular Senescence
  • 강현태 ; 
  • 박준태 ; 
  • 최고봉 ; 
  • 김용섭 ; 
  • 최효제 ; 
  • 정철원 ; 
  • Lee, Young-Sam ; 
  • Park, Sang Chul
  • 2017-07-07
  • 강현태. (2017-07-07). Controlling Aging Restoration of Cellular Senescence. 2017 International Protein Metabolism and Diseases Conference, 65–65.
  • KSMCB
  • View : 77
  • Download : 0
Article
DDS promotes longevity through a microbiome-mediated starvation signal
  • Choi, Haeri ; 
  • Cho, Sung Chun ; 
  • Ha, Young Wan ; 
  • Ocampo, Billie ; 
  • Park, Shirley ; 
  • Chen, Shiwen ; 
  • Bennett, Christopher F. ; 
  • Han, Jeehae ; 
  • Rossner, Ryan ; 
  • Kang, Jong-Sun ; 
    • et al
  • 2019-07
  • Choi, Haeri. (2019-07). DDS promotes longevity through a microbiome-mediated starvation signal. doi: 10.1016/j.tma.2019.07.001
  • KeAi Communications Co.
  • View : 755
  • Download : 0
Article
Diaminodiphenyl sulfone-induced parkin ameliorates age-dependent dopaminergic neuronal loss
  • Lee, Yun Il ; 
  • Kang, Ho Jin ; 
  • Ha, Young Wan ; 
  • Chang, Ki Young ; 
  • Cho, Sung Chun ; 
  • Song, Sang Ok ; 
  • Kim, Hye In ; 
  • Jo, A Reum ; 
  • Khang, Rin ; 
  • Choi, Jeong Yun ; 
    • et al
  • 2016
  • Lee, Yun Il. (2016). Diaminodiphenyl sulfone-induced parkin ameliorates age-dependent dopaminergic neuronal loss. Neurobiology of Aging, 41, 1–10. doi: 10.1016/j.neurobiolaging.2015.11.008
  • Elsevier Inc.
  • View : 911
  • Download : 0

Disruption of nucleocytoplasmic trafficking as a cellular senescence driver

Article
Disruption of nucleocytoplasmic trafficking as a cellular senescence driver
  • Park, Ji-Hwan ; 
  • Ryu, Sung Jin ; 
  • Kim, Byung Ju ; 
  • Cho, Hyun-Ji ; 
  • Park, Chi Hyun ; 
  • Choi, Hyo Jei Claudia ; 
  • Jang, Eun Jin ; 
  • Yang, Eun Jae ; 
  • Hwang, Jeong-A ; 
  • Woo, Seung Hwa ; 
    • et al
  • 2021-06
  • Experimental & Molecular Medicine, v.53, no.6, pp.1092 - 1108
  • Springer Nature
  • View : 1108
  • Download : 247
Article
Ethnic food for longevity pursuit: assessment of Korean ethnic food
  • Park, Sang Chul
  • 2016-09
  • Park, Sang Chul. (2016-09). Ethnic food for longevity pursuit: assessment of Korean ethnic food. Journal of Ethnic Foods, 3(3), 167–170. doi: 10.1016/j.jef.2016.08.004
  • 한국식품연구원
  • View : 569
  • Download : 0
Article
Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate
  • Bae, Ju-Hyeon ; 
  • Jo, Areum ; 
  • Cho, Sung Chun ; 
  • Lee, Yun-Il ; 
  • Kam, Tae-In ; 
  • You, Chang-Lim ; 
  • Jeong, Hyeon-Ju ; 
  • Kim, Hyebeen ; 
  • Jeong, Myong-Ho ; 
  • Jeong, Yideul ; 
    • et al
  • 2023-08
  • Bae, Ju-Hyeon. (2023-08). Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate. Science Translational Medicine, 15(711). doi: 10.1126/scitranslmed.abh3489
  • American Association for the Advancement of Science
  • View : 502
  • Download : 0

Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues

Article
Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues
  • 2020-08
  • Experimental & Molecular Medicine, v.52, no.8, pp.1351 - 1359
  • Springer Nature
  • View : 821
  • Download : 197

Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model

Article
Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model
  • Ham, Sangwoo ; 
  • Lee, Yun-Il ; 
  • Jo, Minkyung ; 
  • Kim, Hyojung ; 
  • Kang, Hojin ; 
  • Jo, Areum ; 
  • Lee, Gum Hwa ; 
  • Mo, Yun Jeong ; 
  • Park, Sang Chul ; 
  • Lee, Yun Song ; 
    • et al
  • 2017-04
  • Ham, Sangwoo. (2017-04). Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model. Scientific Reports, 7(1). doi: 10.1038/s41598-017-00614-w
  • Nature Publishing Group
  • View : 992
  • Download : 246
Article
Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice
  • Kim, Hyojung ; 
  • Huh, Yu-Jin ; 
  • Kim, Ji Hun ; 
  • Jo, Minkyung ; 
  • Shin, Joo-Heon ; 
  • Park, Sang Chul ; 
  • Ahn, Jee-Yin ; 
  • Lee, Yun-Il ; 
  • Lee, Yunjong
  • 2023-01
  • Kim, Hyojung. (2023-01). Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice. Frontiers in Aging Neuroscience, 14. doi: 10.3389/fnagi.2022.1030807
  • Frontiers Media S.A.
  • View : 167
  • Download : 0

Identification of SYK inhibitor, R406 as a novel senolytic agent

Article
Identification of SYK inhibitor, R406 as a novel senolytic agent
  • Cho, Hyun-Ji ; 
  • Yang, Eun Jae ; 
  • Park, Joon Tae ; 
  • Kim, Jae-Ryong ; 
  • Kim, Eok-Cheon ; 
  • Jung, Kyong-Jin ; 
  • Park, Sang Chul ; 
  • Lee, Young-Sam
  • 2020-05
  • Cho, Hyun-Ji. (2020-05). Identification of SYK inhibitor, R406 as a novel senolytic agent. doi: 10.18632/aging.103135
  • Impact Journals
  • View : 829
  • Download : 167
Article
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice
  • Kim, Ok-Hee ; 
  • Kim, Hyojung ; 
  • Kang, Jinku ; 
  • Yang, Dongki ; 
  • Kang, Yu-Hoi ; 
  • Lee, Dae Ho ; 
  • Cheon, Gi Jeong ; 
  • Park, Sang Chul ; 
  • Oh, Byung-Chul
  • 2017-01
  • BMB Reports, v.50, no.1, pp.43 - 48
  • The Biochemical Society of the Republic of Korea
  • View : 1004
  • Download : 0

Microvasculature remodeling in the mouse lower gut during inflammaging

Article
Microvasculature remodeling in the mouse lower gut during inflammaging
  • Jeong, Jae-Ho ; 
  • Kim, KwangSoo ; 
  • Lim, Daejin ; 
  • Kim, Kun-Hee ; 
  • Kim, Hyung-Seok ; 
  • Lee, Sungsu ; 
  • Song, Joo-Hye ; 
  • Moon, Byoung-Gon ; 
  • Choy, Hyon E. ; 
  • Park, Sang Chul
  • 2017-01
  • Jeong, Jae-Ho. (2017-01). Microvasculature remodeling in the mouse lower gut during inflammaging. Scientific Reports, 7. doi: 10.1038/srep39848
  • Nature Publishing Group
  • View : 683
  • Download : 112
Article
Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence
  • Kim, Jae Won ; 
  • Kuk, Myeong Uk ; 
  • Choy, Hyon E. ; 
  • Park, Sang Chul ; 
  • Park, Joon Tae
  • 2019-10
  • Kim, Jae Won. (2019-10). Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence. doi: 10.1016/j.exger.2019.110691
  • Elsevier Inc.
  • View : 610
  • Download : 0

Nintedanib induces senolytic effect via STAT3 inhibition

Article
Nintedanib induces senolytic effect via STAT3 inhibition
  • Cho, Hyun-Ji ; 
  • Hwang, Jeong-A ; 
  • Yang, Eun Jae ; 
  • Kim, Eok-Cheon ; 
  • Kim, Jae-Ryong ; 
  • Kim, Sung Young ; 
  • Kim, Young Zoon ; 
  • Park, Sang Chul ; 
  • Lee, Young-Sam
  • 2022-09
  • Cho, Hyun-Ji. (2022-09). Nintedanib induces senolytic effect via STAT3 inhibition. Cell Death and Disease, 13(9). doi: 10.1038/s41419-022-05207-8
  • Nature Publishing Group
  • View : 426
  • Download : 15
Article
Quantification of Autophagy During Senescence
  • 2019
  • Park, Joon Tae. (2019). Quantification of Autophagy During Senescence. doi: 10.1007/978-1-4939-8931-7_14
  • Humana Press Inc.
  • View : 700
  • Download : 0
Article
Serendipity in search for longevity from experiences of Hansen people
  • Park, Sang Chul
  • 2017-10
  • Park, Sang Chul. (2017-10). Serendipity in search for longevity from experiences of Hansen people. Translational Medicine of Aging, 1, 12–17. doi: 10.1016/j.tma.2017.06.001
  • KeAi Communications Co., Ltd.
  • View : 114
  • Download : 0
Article
Silver electroceutical technology to treat sarcopenia
  • Kim, Min. Young. ; 
  • Shin, Hyun Young ; 
  • Cho, Sung Chun ; 
  • Yang, Sohae ; 
  • Tasnuf, Aseer Intisar ; 
  • Woo, Hyeong Jung ; 
  • Choi, Youn-Suk ; 
  • You, Chang-Lim ; 
  • Kang, Jong-Sun ; 
  • Lee, Yun-Il ; 
    • et al
  • 2023-08
  • Kim, Min. Young. (2023-08). Silver electroceutical technology to treat sarcopenia. Proceedings of the National Academy of Sciences of the United States of America, 120(33). doi: 10.1073/pnas.2300036120
  • National Academy of Sciences
  • View : 465
  • Download : 0

Survive or thrive: tradeoff strategy for cellular senescence

Article
Survive or thrive: tradeoff strategy for cellular senescence
  • Park, Sang Chul
  • 2017-06
  • Experimental & Molecular Medicine, v.49, no.6
  • Nature Publishing Group
  • View : 653
  • Download : 96

Systematic identification of an integrative network module during senescence from time-series gene expression

Article
Systematic identification of an integrative network module during senescence from time-series gene expression
  • Park, Chihyun ; 
  • Yun, So Jeong ; 
  • Ryu, Sung Jin ; 
  • Lee, Soyoung ; 
  • Lee, Young-Sam ; 
  • Yoon, Youngmi ; 
  • Park, Sang Chul
  • 2017-03
  • Park, Chihyun. (2017-03). Systematic identification of an integrative network module during senescence from time-series gene expression. BMC Systems Biology, 11(1). doi: 10.1186/s12918-017-0417-1
  • BIOMED CENTRAL LTD
  • View : 945
  • Download : 147
Article
What matters in aging is signaling for responsiveness
  • Park, Sang Chul ; 
  • Lee, Young-Sam ; 
  • Cho, Kyung A ; 
  • Kim, Sung Young ; 
  • Lee, Yun-Il ; 
  • Lee, Seung-Rock ; 
  • Lim, In Kyoung
  • 2023-12
  • Park, Sang Chul. (2023-12). What matters in aging is signaling for responsiveness. Pharmacology and Therapeutics, 252. doi: 10.1016/j.pharmthera.2023.108560
  • Elsevier Inc.
  • View : 263
  • Download : 0

ZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts

Article
ZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts
  • Bae, Ju-Hyeon ; 
  • Jeong, Hyeon-Ju ; 
  • Kim, Hyebeen ; 
  • Leem, Young-Eun ; 
  • Ryu, Dongryeol ; 
  • Park, Sang Chul ; 
  • Lee, Yun-Il ; 
  • Cho, Sung Chun ; 
  • Kang, Jong-Sun
  • 2020-05
  • Bae, Ju-Hyeon. (2020-05). ZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts. doi: 10.1038/s41419-020-2552-7
  • Nature Publishing Group
  • View : 699
  • Download : 79
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