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Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse

Title
Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse
Authors
Kim, Jae YeonCho, BongkiMoon, Cheil
DGIST Authors
Kim, Jae Yeon; Cho, Bongki; Moon, Cheil
Issue Date
2020-01
Citation
Cell Reports, 30(1), 187-201
Type
Article
Article Type
Article
Keywords
animal cellanimal experimentarticleinterneuronmousenervous system developmentnonhumanolfactory bulb
ISSN
2211-1247
Abstract
Kim et al. reveal that Abl1 is required in early-born olfactory bulb (OB) interneurons during postnatal neurodevelopment. The Abl1-Dcx axis regulates OB circuit formation to support innate olfactory behaviors. The authors propose that Abl1-Dcx is the crucial temporal-specific signal underlying anatomical and/or functional development of postnatal early-born OB interneurons. © 2019 The Author(s)More than one-half of the interneurons in a mouse olfactory bulb (OB) develop during the first week after birth and predominantly connect to excitatory tufted cells near the superficial granule cell layer (sGCL), unlike late-born interneurons. However, the molecular mechanisms underlying the temporal specification are yet to be identified. In this study, we determined the role of Abelson tyrosine-protein kinase 1 (Abl1) in the temporal development of early-born OB interneurons. Lentiviral knockdown of Abl1 disrupts the sGCL circuit of early-born interneurons through defects in function and circuit integration, resulting in olfactory hyper-sensitivity. We show that doublecortin (Dcx) is phosphorylated by Abl1, which contributes to the stabilization of Dcx, thereby regulating microtubule dynamics. Finally, Dcx overexpression rescues Abl1 knockdown-induced anatomic or functional defects. In summary, specific signaling by Abl1-Dcx in early-born interneurons facilitates the temporal development of the sGCL circuit to regulate innate olfactory functions, such as detection and sensitivity. © 2019 The Author(s)
URI
http://hdl.handle.net/20.500.11750/11395
DOI
10.1016/j.celrep.2019.12.004
Publisher
Cell Press
Related Researcher
  • Author Moon, Cheil Laboratory of Chemical Senses
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
Collection:
Division of Biotechnology1. Journal Articles
Department of Brain and Cognitive SciencesLaboratory of Chemical Senses1. Journal Articles


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