Cited time in webofscience Cited time in scopus

Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse

Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse
Kim, Jae YeonCho, BongkiMoon, Cheil
Issued Date
Cell Reports, v.30, no.1, pp.187 - 201
animal cellanimal experimentarticleinterneuronmousenervous system developmentnonhumanolfactory bulb
Kim et al. reveal that Abl1 is required in early-born olfactory bulb (OB) interneurons during postnatal neurodevelopment. The Abl1-Dcx axis regulates OB circuit formation to support innate olfactory behaviors. The authors propose that Abl1-Dcx is the crucial temporal-specific signal underlying anatomical and/or functional development of postnatal early-born OB interneurons. © 2019 The Author(s)More than one-half of the interneurons in a mouse olfactory bulb (OB) develop during the first week after birth and predominantly connect to excitatory tufted cells near the superficial granule cell layer (sGCL), unlike late-born interneurons. However, the molecular mechanisms underlying the temporal specification are yet to be identified. In this study, we determined the role of Abelson tyrosine-protein kinase 1 (Abl1) in the temporal development of early-born OB interneurons. Lentiviral knockdown of Abl1 disrupts the sGCL circuit of early-born interneurons through defects in function and circuit integration, resulting in olfactory hyper-sensitivity. We show that doublecortin (Dcx) is phosphorylated by Abl1, which contributes to the stabilization of Dcx, thereby regulating microtubule dynamics. Finally, Dcx overexpression rescues Abl1 knockdown-induced anatomic or functional defects. In summary, specific signaling by Abl1-Dcx in early-born interneurons facilitates the temporal development of the sGCL circuit to regulate innate olfactory functions, such as detection and sensitivity. © 2019 The Author(s)
Cell Press
Related Researcher
  • 문제일 Moon, Cheil 뇌과학과
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files in This Item:

There are no files associated with this item.

Appears in Collections:
Department of Brain Sciences Laboratory of Chemical Senses 1. Journal Articles
Division of Biotechnology 1. Journal Articles


  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.