Cited 9 time in webofscience Cited 4 time in scopus

A magnetically actuated microrobot for targeted neural cell delivery and selective connection of neural networks

Title
A magnetically actuated microrobot for targeted neural cell delivery and selective connection of neural networks
Authors
Kim, EunheeJeon, SungwoongAn, Hyun-KyuKianpour, MehrnooshYu, Seong-WoonKim, Jin-youngRah, Jong-CheolChoi, Hongsoo
DGIST Authors
Yu, Seong-WoonKim, Jin-youngChoi, Hongsoo
Issue Date
2020-09
Citation
Science Advances, 6(39), eabb5696
Type
Article
Article Type
Article
Keywords
CENTRAL-NERVOUS-SYSTEMNEURONSGROWTHMEMORYFABRICATIONPLASTICITYGUIDANCEPOLARITYCULTURE
ISSN
2375-2548
Abstract
There has been a great deal of interest in the development of technologies for actively manipulating neural networks in vitro, providing natural but simplified environments in a highly reproducible manner in which to study brain function and related diseases. Platforms for these in vitro neural networks require precise and selective neural connections at the target location, with minimal external influences, and measurement of neural activity to determine how neurons communicate. Here, we report a neuron-loaded microrobot for selective connection of neural networks via precise delivery to a gap between two neural clusters by an external magnetic field. In addition, the extracellular action potential was propagated from one cluster to the other through the neurons on the microrobot. The proposed technique shows the potential for use in experiments to understand how neurons communicate in the neural network by actively connecting neural clusters. Copyright © 2020 The Authors, some rights reserved.
URI
http://hdl.handle.net/20.500.11750/12440
DOI
10.1126/sciadv.abb5696
Publisher
American Association for the Advancement of Science
Related Researcher
  • Author Yu, Seong-Woon Laboratory of Neuronal Cell Death
  • Research Interests Molecular mechanisms of neuronal cell death and neurodegeneration
Files:
Collection:
Department of Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


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