Cited 7 time in webofscience Cited 8 time in scopus

Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function

Title
Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function
Authors
Kim, Hee YoungUm, Ji WonKo, Jaewon
DGIST Authors
Kim, Hee Young; Um, Ji WonKo, Jaewon
Issue Date
2021-05
Citation
Progress in Neurobiology, 200
Type
Article
Article Type
Article in press
Author Keywords
synaptic adhesionneurexinLAR-RPTPneural circuitcognitive function
ISSN
0301-0082
Abstract
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse development and specifying neural circuit properties via the formation of multifarious signaling pathways. Recent studies have pinpointed the putative roles of trans-synaptic cell-adhesion molecules in mediating various cognitive functions. Here, we review the literature on the roles of a diverse group of central synaptic organizers, including neurexins (Nrxns), leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs), and their associated binding proteins, in regulating properties of specific type of synapses and neural circuits. In addition, we highlight the findings that aberrant synaptic adhesion signaling leads to alterations in the structures, transmission, and plasticity of specific synapses across diverse brain areas. These results seem to suggest that proper trans-synaptic signaling pathways by Nrxns, LAR-RPTPs, and their interacting network is likely to constitute central molecular complexes that form the basis for cognitive functions, and that these complexes are heterogeneously and complexly disrupted in many neuropsychiatric and neurodevelopmental disorders. © 2020 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/12619
DOI
10.1016/j.pneurobio.2020.101983
Publisher
Pergamon Press Ltd.
Related Researcher
  • Author Ko, Jaewon Laboratory of Synapse Formation and Function
  • Research Interests Synapse Formation and Function; Neural Circuits; 뇌질환; animal model
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesSynapse Disorder Laboratory1. Journal Articles
Department of Brain and Cognitive SciencesLaboratory of Synapse Formation and Function1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE