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Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function

Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function
Kim, Hee YoungUm, Ji WonKo, Jaewon
DGIST Authors
Kim, Hee YoungUm, Ji WonKo, Jaewon
Issued Date
Article Type
Article in press
Author Keywords
synaptic adhesionneurexinLAR-RPTPneural circuitcognitive function
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse development and specifying neural circuit properties via the formation of multifarious signaling pathways. Recent studies have pinpointed the putative roles of trans-synaptic cell-adhesion molecules in mediating various cognitive functions. Here, we review the literature on the roles of a diverse group of central synaptic organizers, including neurexins (Nrxns), leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs), and their associated binding proteins, in regulating properties of specific type of synapses and neural circuits. In addition, we highlight the findings that aberrant synaptic adhesion signaling leads to alterations in the structures, transmission, and plasticity of specific synapses across diverse brain areas. These results seem to suggest that proper trans-synaptic signaling pathways by Nrxns, LAR-RPTPs, and their interacting network is likely to constitute central molecular complexes that form the basis for cognitive functions, and that these complexes are heterogeneously and complexly disrupted in many neuropsychiatric and neurodevelopmental disorders. © 2020 Elsevier Ltd. All rights reserved.
Pergamon Press Ltd.
Related Researcher
  • 엄지원 Um, Ji Won 뇌과학과
  • Research Interests Molecular and cellular mechanisms underlying synapse elimination; Key synaptic mechanisms associated with Alzheimer's disease and autism spectrum disorders; Synaptic homeostasis
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Appears in Collections:
Department of Brain Sciences Laboratory of Synapse Formation and Function 1. Journal Articles
Department of Brain Sciences Synapse Disorder Laboratory 1. Journal Articles


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