Cited 7 time in webofscience Cited 5 time in scopus

Active delivery of multi-layer drug-loaded microneedle patches using magnetically driven capsule

Title
Active delivery of multi-layer drug-loaded microneedle patches using magnetically driven capsule
Authors
Lee, JihunLee, HyoryongKwon, Su-hyunPark, Sukho
DGIST Authors
Lee, Jihun; Lee, Hyoryong; Kwon, Su-hyun; Park, Sukho
Issue Date
2020-11
Citation
Medical Engineering and Physics, 85, 87-96
Type
Article
Article Type
Article
Author Keywords
Multi-layer microneedleMagnetically driven capsuleGastrointestinal drug deliveryActive drug delivery
Keywords
FABRICATIONSYSTEM
ISSN
1350-4533
Abstract
In this paper, we propose the active delivery of multi-layer drug-loaded microneedle (MN) patches using a capsule that can be driven by an external magnetic field. Firstly, the multi-layer drug-loaded MN patches consist of three delivered MN patches which are composed of a drug-loaded MN patch and polydimethylsiloxane layer. The drug-loaded MN patch is made of a 10% gelatin solution and a drug. The multi-layer MN patches are attached to a permanent magnet in a magnetically driven capsule. Under an external magnetic field generated by an electromagnetic actuation system, the capsule with the multi-layer MN patches can reach the target lesions, and each MN patch can be delivered to the target lesions for medical treatment. The active delivery of the multi-layer MN patches using the proposed magnetically driven capsule was confirmed via phantom experiments. Accordingly, the adhesion of the three separated faces of the multi-layer MN patches and the adhesion between the porcine small intestine and the MN patch were measured using a load cell. We demonstrate the feasibility of the active delivery of the multi-layer MN patches to the target lesions on a porcine small intestine. Consequently, we expect that the active delivery of the multi-layer drug-loaded MN patches using the magnetically driven capsule presented in this study can be a useful method for drug delivery to lesions at various locations in the gastrointestinal tract. © 2020
URI
http://hdl.handle.net/20.500.11750/12686
DOI
10.1016/j.medengphy.2020.09.012
Publisher
Elsevier BV
Related Researcher
  • Author Park, Sukho Multiscale Biomedical Robotics Laboratory
  • Research Interests Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringMultiscale Biomedical Robotics Laboratory1. Journal Articles


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