Human cells can pack nearly ~2 meters of DNA into a ~10μm nucleus, while still being able to accurately read, replicate, and segregate this tightly condensed genome. Each of us has enough DNA to reach from here to the sun and back, more than 300 times.
How is that entire genomic DNA organized in a tiny nucleus? How does the nucleus maintain this vast amount of information throughout life and how is it connected to human aging and diseases?
Our research group aims to decipher the molecular mechanisms that allow cells to organize and maintain their genome throughout the life. We pursue to deepen our understanding by using approaches that integrate single-molecule biophysics, cell imaging and computational analysis, nano/micro engineering and molecular biology.
Advisor Professor : Kim, Yoori
Chromatin Organization and Protein Dynamics Lab Homepage