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DC Field Value Language Park, Ji-Hwan - Ryu, Sung Jin - Kim, Byung Ju - Cho, Hyun-Ji - Park, Chi Hyun - Choi, Hyo Jei Claudia - Jang, Eun Jin - Yang, Eun Jae - Hwang, Jeong-A - Woo, Seung Hwa - Lee, Jun Hyung - Park, Ji Hwan - Choi, Kyung-Mi - Kwon, Young-Yon - Lee, Cheol-Koo - Park, Joon Tae - Cho, Sung Chun - Lee, Yun-Il - Lee, Sung Bae - Han, Jeong A. - Cho, Kyung A. - Kim, Min-Sik - Hwang, Daehee - Lee, Young-Sam - Park, Sang Chul - 2021-08-24T20:06:23Z - 2021-08-24T20:06:23Z - 2021-07-08 - 2021-06 -
dc.identifier.citation Experimental and Molecular Medicine, v.53, no.6, pp.1092 - 1108 -
dc.identifier.issn 1226-3613 -
dc.identifier.uri -
dc.description.abstract Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This diminished reaction may be explained by the disrupted transmission of nuclear signals. However, this hypothesis requires more evidence before it can be accepted as a mechanism of cellular senescence. A proteomic analysis of the cytoplasmic and nuclear fractions obtained from young and senescent cells revealed disruption of nucleocytoplasmic trafficking (NCT) as an essential feature of replicative senescence (RS) at the global level. Blocking NCT either chemically or genetically induced the acquisition of an RS-like senescence phenotype, named nuclear barrier-induced senescence (NBIS). A transcriptome analysis revealed that, among various types of cellular senescence, NBIS exhibited a gene expression pattern most similar to that of RS. Core proteomic and transcriptomic patterns common to both RS and NBIS included upregulation of the endocytosis-lysosome network and downregulation of NCT in senescent cells, patterns also observed in an aging yeast model. These results imply coordinated aging-dependent reduction in the transmission of extrinsic signals to the nucleus and in the nucleus-to-cytoplasm supply of proteins/RNAs. We further showed that the aging-associated decrease in Sp1 transcription factor expression was critical for the downregulation of NCT. Our results suggest that NBIS is a modality of cellular senescence that may represent the nature of physiological aging in eukaryotes. © 2021, The Author(s). -
dc.language English -
dc.publisher Springer Nature -
dc.title Disruption of nucleocytoplasmic trafficking as a cellular senescence driver -
dc.type Article -
dc.identifier.doi 10.1038/s12276-021-00643-6 -
dc.identifier.wosid 000668062100001 -
dc.identifier.scopusid 2-s2.0-85108980772 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Experimental and Molecular Medicine -
dc.identifier.kciid ART002730419 -
dc.contributor.nonIdAuthor Park, Ji-Hwan -
dc.contributor.nonIdAuthor Ryu, Sung Jin -
dc.contributor.nonIdAuthor Kim, Byung Ju -
dc.contributor.nonIdAuthor Park, Chi Hyun -
dc.contributor.nonIdAuthor Choi, Hyo Jei Claudia -
dc.contributor.nonIdAuthor Yang, Eun Jae -
dc.contributor.nonIdAuthor Hwang, Jeong-A -
dc.contributor.nonIdAuthor Woo, Seung Hwa -
dc.contributor.nonIdAuthor Lee, Jun Hyung -
dc.contributor.nonIdAuthor Park, Ji Hwan -
dc.contributor.nonIdAuthor Choi, Kyung-Mi -
dc.contributor.nonIdAuthor Kwon, Young-Yon -
dc.contributor.nonIdAuthor Lee, Cheol-Koo -
dc.contributor.nonIdAuthor Park, Joon Tae -
dc.contributor.nonIdAuthor Cho, Sung Chun -
dc.contributor.nonIdAuthor Han, Jeong A. -
dc.contributor.nonIdAuthor Cho, Kyung A. -
dc.contributor.nonIdAuthor Hwang, Daehee -
dc.contributor.nonIdAuthor Park, Sang Chul -
dc.identifier.citationVolume 53 -
dc.identifier.citationNumber 6 -
dc.identifier.citationStartPage 1092 -
dc.identifier.citationEndPage 1108 -
dc.identifier.citationTitle Experimental and Molecular Medicine -
dc.description.isOpenAccess Y -
dc.subject.keywordPlus APOPTOSIS -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus IDENTIFICATION -
dc.subject.keywordPlus CLEARANCE -
dc.subject.keywordPlus TRANSCRIPTION FACTOR SP1 -
dc.subject.keywordPlus REPLICATIVE SENESCENCE -
dc.subject.keywordPlus DOWN-REGULATION -
dc.subject.keywordPlus STRESS -
dc.contributor.affiliatedAuthor Park, Ji-Hwan -
dc.contributor.affiliatedAuthor Ryu, Sung Jin -
dc.contributor.affiliatedAuthor Kim, Byung Ju -
dc.contributor.affiliatedAuthor Cho, Hyun-Ji -
dc.contributor.affiliatedAuthor Park, Chi Hyun -
dc.contributor.affiliatedAuthor Choi, Hyo Jei Claudia -
dc.contributor.affiliatedAuthor Jang, Eun Jin -
dc.contributor.affiliatedAuthor Yang, Eun Jae -
dc.contributor.affiliatedAuthor Hwang, Jeong-A -
dc.contributor.affiliatedAuthor Woo, Seung Hwa -
dc.contributor.affiliatedAuthor Lee, Jun Hyung -
dc.contributor.affiliatedAuthor Park, Ji Hwan -
dc.contributor.affiliatedAuthor Choi, Kyung-Mi -
dc.contributor.affiliatedAuthor Kwon, Young-Yon -
dc.contributor.affiliatedAuthor Lee, Cheol-Koo -
dc.contributor.affiliatedAuthor Park, Joon Tae -
dc.contributor.affiliatedAuthor Cho, Sung Chun -
dc.contributor.affiliatedAuthor Lee, Yun-Il -
dc.contributor.affiliatedAuthor Lee, Sung Bae -
dc.contributor.affiliatedAuthor Han, Jeong A. -
dc.contributor.affiliatedAuthor Cho, Kyung A. -
dc.contributor.affiliatedAuthor Kim, Min-Sik -
dc.contributor.affiliatedAuthor Hwang, Daehee -
dc.contributor.affiliatedAuthor Lee, Young-Sam -
dc.contributor.affiliatedAuthor Park, Sang Chul -


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