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A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery

A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery
Kang, Yoo NaChou, NamsunJang, Jae-WonChoe, Han KyoungKim, Sohee
DGIST Authors
Kang, Yoo NaChou, NamsunJang, Jae-WonChoe, Han KyoungKim, Sohee
Issued Date
CablesChlorine compoundsMicroelectrodesMicrofluidicsNeedlesNeural networksNeurologyPotassium compoundsTargeted drug delivery3-dimensional structuresBiological mechanismsCharacteristic threeMicroelectrode arrayMicrofluidic channelNeural interfacesNeurological diseaseSignal recordingControlled drug delivery
The demand for multifunctional neural interfaces has grown due to the need to provide a better understanding of biological mechanisms related to neurological diseases and neural networks. Direct intracerebral drug injection using microfluidic neural interfaces is an effective way to deliver drugs to the brain, and it expands the utility of drugs by bypassing the blood–brain barrier (BBB). In addition, uses of implantable neural interfacing devices have been challenging due to inevitable acute and chronic tissue responses around the electrodes, pointing to a critical issue still to be overcome. Although neural interfaces comprised of a collection of microneedles in an array have been used for various applications, it has been challenging to integrate microfluidic channels with them due to their characteristic three-dimensional structures, which differ from two-dimensionally fabricated shank-type neural probes. Here we present a method to provide such three-dimensional needle-type arrays with chemical delivery functionality. We fabricated a microfluidic interconnection cable (µFIC) and integrated it with a flexible penetrating microelectrode array (FPMA) that has a 3-dimensional structure comprised of silicon microneedle electrodes supported by a flexible array base. We successfully demonstrated chemical delivery through the developed device by recording neural signals acutely from in vivo brains before and after KCl injection. This suggests the potential of the developed microfluidic neural interface to contribute to neuroscience research by providing simultaneous signal recording and chemical delivery capabilities. © 2021, The Author(s).
Springer Nature
Related Researcher
  • 최한경 Choe, Han Kyoung 뇌과학과
  • Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
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Appears in Collections:
Department of Brain Sciences Laboratory of Animal Behavior and Circadian rhythm 1. Journal Articles
Department of Robotics and Mechatronics Engineering Neural Interfaces & MicroSystems Lab 1. Journal Articles


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