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Highly bioactive and low cytotoxic Si-based NiOOH nanoflowers targeted against various bacteria, including MRSA, and their potential antibacterial mechanism

Title
Highly bioactive and low cytotoxic Si-based NiOOH nanoflowers targeted against various bacteria, including MRSA, and their potential antibacterial mechanism
Authors
Gwon, KihakPark, Jong-DeokLee, SeonhwaHan, IhnYu, Jong-SungLee, Do Nam
DGIST Authors
Gwon, Kihak; Park, Jong-Deok; Lee, Seonhwa; Han, Ihn; Yu, Jong-Sung; Lee, Do Nam
Issue Date
2021-07
Citation
Journal of Industrial and Engineering Chemistry, 99, 264-270
Type
Article
Author Keywords
Antibacterial activityCytotoxicityElectrochemical propertyMechanismSi-based nanoflowerSurface area
Keywords
Redox reactionsShells (structures)SiliconSilicon compoundsTissue regenerationAnti-bacterial activityAntibacterial mechanismsChemical bath deposition methodsKlebsiella pneumoniaeLow cytotoxicitiesMethicillin-resistant staphylococcus aureusMouse embryonic fibroblastsPseudomonas aeruginosaNickel compoundsAntimicrobial agentsAscorbic acidBacteriaCell cultureImplants (surgical)Metal ionsMetalsMorphologyNanoflowers
ISSN
1226-086X
Abstract
With the emergence of new drug-resistant microorganisms, the development of effective antimicrobial agents is urgently required. Core-shell-structured nanomaterials have received considerable attention as antibacterial agents. We prepared a bioactive core-shell-structured silicon-based NiOOH nanoflower (Si@NiOOH) targeted against various bacteria using a modified chemical bath deposition method. Further, we investigated its potential antibacterial mechanism by evaluating electrochemical properties in a redox reaction with ascorbic acid, measuring metal ion release, and analyzing the surface area. The bactericidal rate of Si@NiOOH at 200 μg/mL towards Pseudomonas aeruginosa, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus was as high as 99.9%. Si@NiOOH maintained its original morphology after killing the bacteria and exhibited negligible cytotoxicity towards mouse embryonic fibroblasts. The excellent antibacterial activities of Si@NiOOH are possibly derived from its high surface area, providing a wide active site attached to the cell wall, and the high oxidative potency of the Ni(III) cations existing on its surface. The high antibacterial activity and low cytotoxicity of the nanoflower make it a promising tool for promoting wound healing and for use with medical devices and implants. © 2021 The Korean Society of Industrial and Engineering Chemistry
URI
http://hdl.handle.net/20.500.11750/15480
DOI
10.1016/j.jiec.2021.04.038
Publisher
한국공업화학회
Related Researcher
  • Author Yu, Jong-Sung Light, Salts and Water Research Group
  • Research Interests Materials chemistry; nanomaterials; electrochemistry; carbon and porous materials; fuel cell; battery; supercapacitor; sensor and photochemical catalyst
Files:
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Collection:
Department of Energy Science and EngineeringLight, Salts and Water Research Group1. Journal Articles


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