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Refined prefrontal working memory network as a neuromarker for Alzheimer’s disease

Title
Refined prefrontal working memory network as a neuromarker for Alzheimer’s disease
Author(s)
Kim, EunhoYu, Jin-WooKim, BominLim, Sung‐HoLee, Sang-HoKim, KwangsuSon, GowoonJeon, Hyeon-AeMoon, CheilSakong, JoonChoi, Ji-Woong
DGIST Authors
Kim, EunhoYu, Jin-WooKim, BominLim, Sung‐HoLee, Sang-HoKim, KwangsuSon, GowoonJeon, Hyeon-AeMoon, CheilSakong, JoonChoi, Ji-Woong
Issued Date
2021-11
Type
Article
Keywords
Process varianceWorking memoryInfrared devicesDamage detectionDiagnosisNear infrared spectroscopyAlzheimerBrain damageCognitive processFunctional near infrared spectroscopyIndividual variancesMemory networkNetwork modulationsPrefrontal cortex
ISSN
2156-7085
Abstract
Detecting Alzheimer’s disease (AD) is an important step in preventing pathological brain damage. Working memory (WM)-related network modulation can be a pathological feature of AD, but is usually modulated by untargeted cognitive processes and individual variance, resulting in the concealment of this key information. Therefore, in this study, we comprehensively investigated a new neuromarker, named “refined network,” in a prefrontal cortex (PFC) that revealed the pathological features of AD. A refined network was acquired by removing unnecessary variance from the WM-related network. By using a functional near-infrared spectroscopy (fNIRS) device, we evaluated the reliability of the refined network, which was identified from the three groups classified by AD progression: healthy people (N=31), mild cognitive impairment (N=11), and patients with AD (N=18). As a result, we identified edges with significant correlations between cognitive functions and groups in the dorsolateral PFC. Moreover, the refined network achieved a significantly correlating metric with neuropsychological test scores, and a remarkable three-class classification accuracy (95.0%). These results implicate the refined PFC WM-related network as a powerful neuromarker for AD screening. © 2021 Optical Society of America
URI
http://hdl.handle.net/20.500.11750/15892
DOI
10.1364/BOE.438926
Publisher
The Optical Society

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