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  Department of Brain Sciences Theoretical and Computational Biophysics Laboratory

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Wavenumber-dependent transmission of subthreshold waves on electrical synapses network model of Caenorhabditis elegans

Article
Wavenumber-dependent transmission of subthreshold waves on electrical synapses network model of Caenorhabditis elegans
  • Chang, Iksoo ; 
  • Chung, Taegon ; 
  • Kim, Sangyeol
  • 2025-01
  • Chang, Iksoo. (2025-01). Wavenumber-dependent transmission of subthreshold waves on electrical synapses network model of Caenorhabditis elegans. eLife, 13. doi: 10.7554/eLife.99904
  • eLife Sciences Publications
  • View : 178
  • Download : 18

Resting state of human brain measured by fMRI experiment is governed more dominantly by essential mode as a global signal rather than default mode network

Article
Resting state of human brain measured by fMRI experiment is governed more dominantly by essential mode as a global signal rather than default mode network
  • Park, Kyeongwon ; 
  • Chang, Iksoo ; 
  • Kim, Sangyeol
  • 2024-11
  • Park, Kyeongwon. (2024-11). Resting state of human brain measured by fMRI experiment is governed more dominantly by essential mode as a global signal rather than default mode network. NeuroImage, 301. doi: 10.1016/j.neuroimage.2024.120884
  • Elsevier
  • View : 208
  • Download : 20

Development of equation of motion deciphering locomotion including omega turns of Caenorhabditis elegans

Article
Development of equation of motion deciphering locomotion including omega turns of Caenorhabditis elegans
  • Chung, Taegon ; 
  • Chang, Iksoo ; 
  • Kim, Sangyeol
  • 2024-04
  • eLife, v.12
  • eLife Sciences Publications Ltd
  • View : 322
  • Download : 44
Article
Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease
  • Lee, Juhwan ; 
  • Sim, Kyoung Mi ; 
  • Kang, Mooseok ; 
  • Oh, Hyun Ju ; 
  • Choi, Ho Jung ; 
  • Kim, Yeong Eun ; 
  • Pack, Chan-Gi ; 
  • Kim, Kyunggon ; 
  • Kim, Kyung Mo ; 
  • Oh, Seak Hee ; 
    • et al
  • 2024-01
  • Lee, Juhwan. (2024-01). Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease. Scientific Reports, 14(1). doi: 10.1038/s41598-023-50932-5
  • Nature Publishing Group
  • View : 290
  • Download : 29
Article
Development of quantitative and continuous measure for severity degree of Alzheimer's disease evaluated from MRI images of 761 human brains
  • Kim, Sangyeol ; 
  • Park, Seongjun ; 
  • Chang, Iksoo
  • 2022-08
  • Kim, Sangyeol. (2022-08). Development of quantitative and continuous measure for severity degree of Alzheimer’s disease evaluated from MRI images of 761 human brains. BMC Bioinformatics, 23(1). doi: 10.1186/s12859-022-04903-8
  • BioMed Central
  • View : 329
  • Download : 0
Article
Computational design of a thermolabile uracil-DNA glycosylase of Escherichia coli
  • Park, Seong Jun ; 
  • Shin, Y.-K. ; 
  • Yoon, J.-Y. ; 
  • Nam, K.-H. ; 
  • Munashingha, P.R. ; 
  • Park, S. ; 
  • Park, S.-Y. ; 
  • Kim, S. ; 
  • Lee, Juhwan ; 
  • Seo, Min Jae ; 
    • et al
  • 2022-04
  • Park, Seong Jun. (2022-04). Computational design of a thermolabile uracil-DNA glycosylase of Escherichia coli. Biophysical Journal, 121(7), 1276–1288. doi: 10.1016/j.bpj.2022.02.027
  • Biophysical Society
  • View : 544
  • Download : 0
Article
Interpretation of XIAP Variants of Uncertain Significance in Paediatric Patients with Refractory Crohn's Disease
  • Chang, Iksoo ; 
  • Park, Seong Jun ; 
  • Lee, Hye-Jin ; 
  • Kim, Inki ; 
  • Park, Sojung ; 
  • Ahn, Mi Kyoung ; 
  • Lee, Juhwan ; 
  • Kang, Moo Seok ; 
  • Baek, In-jeoung ; 
  • Sung, Young Hoon ; 
    • et al
  • 2021-08
  • Chang, Iksoo. (2021-08). Interpretation of XIAP Variants of Uncertain Significance in Paediatric Patients with Refractory Crohn's Disease. Journal of Crohn's and Colitis, 15(8), 1291–1304. doi: 10.1093/ecco-jcc/jjab013
  • Oxford University Press
  • View : 558
  • Download : 0

Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies

Article
Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies
  • Kim, Seungjoon ; 
  • Kang, Mooseok ; 
  • Park, Dongseok ; 
  • Lee, Ae-Ree ; 
  • Betz, Heinrich ; 
  • Ko, Jaewon ; 
  • Chang, Iksoo ; 
  • Um, Ji Won
  • 2021-02
  • Kim, Seungjoon. (2021-02). Impaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies. doi: 10.1016/j.isci.2021.102037
  • Cell Press
  • View : 836
  • Download : 573
Article
Detection of hubs in complex networks by the Laplacian matrix
  • Hong, Younghee ; 
  • Chang, Iksoo ; 
  • Kim, Choongrak
  • 2021-06
  • Hong, Younghee. (2021-06). Detection of hubs in complex networks by the Laplacian matrix. Journal of the Korean Statistical Society, 50(2), 431–446. doi: 10.1007/s42952-020-00087-0
  • Springer
  • View : 771
  • Download : 0

Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity

Article
Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity
  • Lee, Juhwan ; 
  • Kang, Mooseok ; 
  • Kim, Sangyeol ; 
  • Chang, Iksoo
  • 2020-04
  • Lee, Juhwan. (2020-04). Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity. PLoS Computational Biology, 16(4), e1007405. doi: 10.1371/journal.pcbi.1007405
  • Public Library of Science
  • View : 681
  • Download : 94

Atomic insights into the effects of pathological mutants through the disruption of hydrophobic core in the prion protein

Article
Atomic insights into the effects of pathological mutants through the disruption of hydrophobic core in the prion protein
  • 2019-12
  • Lee, Ju Hwan. (2019-12). Atomic insights into the effects of pathological mutants through the disruption of hydrophobic core in the prion protein. doi: 10.1038/s41598-019-55661-2
  • Nature Research
  • View : 693
  • Download : 154

Structural insight into conformational change in prion protein by breakage of electrostatic network around H187 due to its protonation

Article
Structural insight into conformational change in prion protein by breakage of electrostatic network around H187 due to its protonation
  • Lee, Ju Hwan ; 
  • Chang, Iksoo
  • 2019-12
  • Lee, Ju Hwan. (2019-12). Structural insight into conformational change in prion protein by breakage of electrostatic network around H187 due to its protonation. doi: 10.1038/s41598-019-55808-1
  • Nature Research
  • View : 828
  • Download : 165

Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction

Article
Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction
  • Naik, Mandar T ; 
  • Kang, Moo Seok ; 
  • Ho, ChunChen ; 
  • Liao, Pei Hsin ; 
  • Hsieh, Yung-Lin ; 
  • Naik, Nandita M ; 
  • Wang, Szu Huan ; 
  • Chang, Ik Soo ; 
  • Shih, Hsiu Ming ; 
  • Huang, Tai Huang
  • 2017-12
  • Naik, Mandar T. (2017-12). Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction. doi: 10.1038/s41598-017-17465-0
  • Nature Publishing Group
  • View : 867
  • Download : 160
Article
Effects of Macromolecular Crowding on Amyloid Beta (16-22) Aggregation Using Coarse-Grained Simulations
  • Latshaw, David C. ; 
  • Cheon, Mookyung ; 
  • Hall, Carol K.
  • 2014-11-27
  • Latshaw, David C. (2014-11-27). Effects of Macromolecular Crowding on Amyloid Beta (16-22) Aggregation Using Coarse-Grained Simulations. Journal of Physical Chemistry B, 118(47), 13513–13526. doi: 10.1021/jp508970q
  • American Chemical Society
  • View : 922
  • Download : 0

Polymorphism of fibrillar structures depending on the size of assembled A beta(17-42) peptides

Article
Polymorphism of fibrillar structures depending on the size of assembled A beta(17-42) peptides
  • Cheon, Mookyung ; 
  • Kang, Mooseok ; 
  • Chang, Iksoo
  • 2016-11
  • Cheon, Mookyung. (2016-11). Polymorphism of fibrillar structures depending on the size of assembled A beta(17-42) peptides. Scientific Reports, 6. doi: 10.1038/srep38196
  • Nature Publishing Group
  • View : 956
  • Download : 163

The C-Domain of the NAC Transcription Factor ANAC019 Is Necessary for pH-Tuned DNA Binding through a Histidine Switch in the N-Domain

Article
The C-Domain of the NAC Transcription Factor ANAC019 Is Necessary for pH-Tuned DNA Binding through a Histidine Switch in the N-Domain
  • Kang, Moo Seok ; 
  • Kim, Sang Yeol ; 
  • Kim, Hyo Jung ; 
  • Shrestha, Pravesh ; 
  • Yun, Ji-Hye ; 
  • Phee, Bong-Kwan ; 
  • Lee, Weontae ; 
  • Nam, Hong Gil ; 
  • Chang, Ik Soo
  • 2018-01
  • Kang, Moo Seok. (2018-01). The C-Domain of the NAC Transcription Factor ANAC019 Is Necessary for pH-Tuned DNA Binding through a Histidine Switch in the N-Domain. doi: 10.1016/j.celrep.2018.01.002
  • Cell Press
  • View : 764
  • Download : 99
Article
Analysis of Phosphoinositide-Binding Properties and Subcellular Localization of GFP-Fusion Proteins
  • Jun, Yong-Woo ; 
  • Kim, Sangyeol ; 
  • Kim, Kun-Hyung ; 
  • Lee, Jin-A ; 
  • Lim, Chae-Seok ; 
  • Chang, Iksoo ; 
  • Suh, Byung-Chang ; 
  • Kaang, Bong-Kiun ; 
  • Jang, Deok-Jin
  • 2015-04
  • Lipids, v.50, no.4, pp.427 - 436
  • Springer Nature
  • View : 1068
  • Download : 0
Article
Uncovering multiloci-ordering by algebraic property of Laplacian matrix and its Fiedler vector
  • Cheon, Mookyung ; 
  • Kim, Choongrak ; 
  • Chang, Iksoo
  • 2016-03-15
  • Cheon, Mookyung. (2016-03-15). Uncovering multiloci-ordering by algebraic property of Laplacian matrix and its Fiedler vector. Bioinformatics, 32(6), 801–807. doi: 10.1093/bioinformatics/btv669
  • Oxford University Press
  • View : 888
  • Download : 0

Structural Conversion of A beta(17-42) Peptides from Disordered Oligomers to U-Shape Protofilaments via Multiple Kinetic Pathways

Article
Structural Conversion of A beta(17-42) Peptides from Disordered Oligomers to U-Shape Protofilaments via Multiple Kinetic Pathways
  • Cheon, Mookyung ; 
  • Hall, Carol K. ; 
  • Chang, Iksoo
  • 2015-05
  • Cheon, Mookyung. (2015-05). Structural Conversion of A beta(17-42) Peptides from Disordered Oligomers to U-Shape Protofilaments via Multiple Kinetic Pathways. PLoS Computational Biology, 11(5). doi: 10.1371/journal.pcbi.1004258
  • Public Library of Science
  • View : 986
  • Download : 139

Probing the Folding-Unfolding Transition of a Thermophilic Protein, MTH1880

Article
Probing the Folding-Unfolding Transition of a Thermophilic Protein, MTH1880
  • Kim, Heeyoun ; 
  • Kim, Sang Yeol ; 
  • Jung, Youngjin ; 
  • Han, Jeongmin ; 
  • Yun, Ji-Hye ; 
  • Chang, Ik Soo ; 
  • Lee, Weontae
  • 2016-01
  • Kim, Heeyoun. (2016-01). Probing the Folding-Unfolding Transition of a Thermophilic Protein, MTH1880. PLoS ONE, 11(1). doi: 10.1371/journal.pone.0145853
  • Public Library of Science
  • View : 1063
  • Download : 111
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