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Magnetically Actuated Microscaffold Containing Mesenchymal Stem Cells for Articular Cartilage Repair

Magnetically Actuated Microscaffold Containing Mesenchymal Stem Cells for Articular Cartilage Repair
Go, GwangjunHan, JiwonZhen, JinZheng, ShaohuiYoo, AmiJeon, Mi-JeongPark, Jong-OhPark, Sukho
DGIST Authors
Park, Sukho
Issue Date
Advanced Healthcare Materials, 6(13)
Article Type
AmineAnimal CellArticular CartilageArticular Cartilage RepairCell AdhesionCell CultureCell DifferentiationCell FunctionCell MigrationCell ProliferationCell ViabilityChemical StructureChondrocytesControlled StudyIronLocomotionMagnetic FieldMagnetic Nano ParticleMaterial CoatingMesenchymal Stem CellMesenchymal Stem CellsMicro EmulsionMicrospheresMouseNanoparticlesNon HumanPolyglactinPorous BeadsPorous Scaffold BeadsPriority JournalRegenerative MedicineScaffoldsSystemTissue RegenerationTissue RepairTissue ScaffoldTransforming Growth Factor Beta 1TransplantationVelocity
This study proposes a magnetically actuated microscaffold with the capability of targeted mesenchymal stem cell (MSC) delivery for articular cartilage regeneration. The microscaffold, as a 3D porous microbead, is divided into body and surface portions according to its materials and fabrication methods. The microscaffold body, which consists of poly(lactic-co-glycolic acid) (PLGA), is formed through water-in-oil-in-water emulsion templating, and its surface is coated with amine functionalized magnetic nanoparticles (MNPs) via amino bond formation. The porous PLGA structure of the microscaffold can assist in cell adhesion and migration, and the MNPs on the microscaffold can make it possible to steer using an electromagnetic actuation system that provides external magnetic fields for the 3D locomotion of the microscaffold. As a fundamental test of the magnetic response of the microscaffold, it is characterized in terms of the magnetization curve, velocity, and 3D locomotion of a single microscaffold. In addition, its function with a cargo of MSCs for cartilage regeneration is demonstrated from the proliferation, viability, and chondrogenic differentiation of D1 mouse MSCs that are cultured on the microscaffold. For the feasibility tests for cartilage repair, 2D/3D targeting of multiple microscaffolds with the MSCs is performed to demonstrate targeted stem cell delivery using the microscaffolds and their swarm motion. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Wiley-VCH Verlag
Related Researcher
  • Author Park, Sukho Multiscale Biomedical Robotics Laboratory
  • Research Interests Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
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Department of Robotics EngineeringMultiscale Biomedical Robotics Laboratory1. Journal Articles

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