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Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans
- Title
- Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans
- Authors
- Hong, Myeongjin; Ryu, Leesun; Ow, Maria C.; Kim, Jinmahn; Je, A. Reum; Chinta, Satya; Huh, Yang Hoon; Lee, Kea Joo; Butcher, Rebecca A.; Choi, Hongsoo; Sengupta, Piali; Hall, Sarah E.; Kim, Kyuhyung
- DGIST Authors
- Hong, Myeongjin; Ryu, Leesun; Ow, Maria C.; Kim, Jinmahn; Je, A. Reum; Chinta, Satya; Huh, Yang Hoon; Lee, Kea Joo; Butcher, Rebecca A.; Choi, Hongsoo; Sengupta, Piali; Hall, Sarah E.; Kim, Kyuhyung
- Issue Date
- 2017
- Citation
- Current Biology, 27(20), 3168-3177.e3
- Type
- Article
- Article Type
- Article
- Author Keywords
- GPI-anchored protein; neuronal activity; pheromone; sensory imprinting; synapse
- Keywords
- NEMATODE CAENORHABDITIS-ELEGANS; OLFACTORY MEMORY; NEURAL CIRCUITS; PATHWAYS; BEHAVIOR; NEURONS
- ISSN
- 0960-9822
- Abstract
- Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-ΔC9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3–7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses. Hong et al. show that early pheromone experience in C. elegans hermaphrodites is imprinted via alteration of activity of a single synaptic connection and, in turn, modulates behavioral responses to the pheromone as adults. © 2017 Elsevier Ltd
- URI
- http://hdl.handle.net/20.500.11750/4631
- DOI
- 10.1016/j.cub.2017.08.068
- Publisher
- Cell Press
- Related Researcher
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Kim, Kyuhyung
The K. Kim Lab of Neurobehavior and Neural Circuits
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Research Interests
Neurobehavior; Neural Circuit; Neurodevelopment; 신경회로; 신경행동; 신경발생; 신경유전학
- Files:
There are no files associated with this item.
- Collection:
- Department of Robotics and Mechatronics EngineeringBio-Micro Robotics Lab1. Journal Articles
Department of Brain SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles
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