Cited 1 time in webofscience Cited 1 time in scopus

Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans

Title
Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans
Authors
Hong, Myeong-JinRyu, Lee-SunOw, Maria C.Kim, JinmahnJe, A ReumChinta, SatyaHuh, Yang HoonLee, Kea JooButcher, Rebecca A.Choi, Hong-SooSengupta, PialiHall, Sarah E.Kim, Kyu-Hyung
DGIST Authors
Hong, Myeong-Jin; Ryu, Lee-Sun; Choi, Hong-SooKim, Kyu-Hyung
Issue Date
2017
Citation
Current Biology, 27(20), 3168-3177.e3
Type
Article
Article Type
Article
ISSN
0960-9822
Abstract
Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-ΔC9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3–7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses. Hong et al. show that early pheromone experience in C. elegans hermaphrodites is imprinted via alteration of activity of a single synaptic connection and, in turn, modulates behavioral responses to the pheromone as adults. © 2017 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/4631
DOI
10.1016/j.cub.2017.08.068
Publisher
Cell Press
Related Researcher
  • Author Kim, Kyu Hyung The K. Kim Lab of Neurobehavior and Neural Circuits
  • Research Interests Neurobehavior; Neural Circuit; Neurodevelopment; 신경회로; 신경행동; 신경발생; 신경유전학
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles
Department of Brain and Cognitive SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE