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Early assessment of tumor response to photodynamic therapy using combined diffuse optical and diffuse correlation spectroscopy to predict treatment outcome

Title
Early assessment of tumor response to photodynamic therapy using combined diffuse optical and diffuse correlation spectroscopy to predict treatment outcome
Authors
Thong, PatriciaLee, KijoonToh, Hui-JinDong, JingTee, Chuan-SiaLow, Kar-PerngChang, Pui-HaanBhuvaneswari, RamaswamyTan, Ngian-ChyeSoo, Khee-Chee
DGIST Authors
Lee, Kijoon
Issue Date
2017-03
Citation
Oncotarget, 8(12), 19902-19913
Type
Article
Article Type
Article
Keywords
Antitumor ImmunityBlood FlowCancerCell DeathCoherence TomographyEfficacyFluence RateModelOptical SpectroscopyOptical SpectroscopyPDTPhotodynamic Therapy (PDT)Photodynamic Therapy (PDT)Reflectance SpectroscopyRelative Blood Flow (RBF)Relative Blood Flow (RBF)Tissue OxygenationTissue OxygenationTreatment Response MonitoringTreatment Response Monitoring
ISSN
1949-2553
Abstract
Photodynamic therapy (PDT) of cancer involves the use of a photosensitizer that can be light-activated to eradicate tumors via direct cytotoxicity, damage to tumor vasculature and stimulating the body's immune system. Treatment outcome may vary between individuals even under the same regime; therefore a non-invasive tumor response monitoring system will be useful for personalization of the treatment protocol. We present the combined use of diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to provide early assessment of tumor response. The relative tissue oxygen saturation (rStO2) and relative blood flow (rBF) in tumors were measured using DOS and DCS respectively before and after PDT with reference to baseline values in a mouse model. In complete responders, PDT-induced decreases in both rStO2 and rBF levels were observed at 3 h post-PDT and the rBF remained low until 48 h post-PDT. Recovery of these parameters to baseline values was observed around 2 weeks after PDT. In partial responders, the rStO2 and rBF levels also decreased at 3 h post PDT, however the rBF values returned toward baseline values earlier at 24 h post-PDT. In contrast, the rStO2 and rBF readings in control tumors showed fluctuations above the baseline values within the first 48 h. Therefore tumor response can be predicted at 3 to 48 h post-PDT. Recovery or sustained decreases in the rBF at 48 h post-PDT corresponded to long-term tumor control. Diffuse optical measurements can thus facilitate early assessment of tumor response. This approach can enable physicians to personalize PDT treatment regimens for best outcomes.
URI
http://hdl.handle.net/20.500.11750/5012
DOI
10.18632/oncotarget.15720
Publisher
Impact Journals LLC
Related Researcher
  • Author Lee, Kijoon  
  • Research Interests Biomedical Optics; DOT; DSCA; NIRS; OCT; LSCI; Nonlinear Optics; Random Laser; Coherent Backscattering
Files:
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Collection:
School of Undergraduate Studies1. Journal Articles


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