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Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry

Title
Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry
Author(s)
Ban, H. Y.Schweiger, M.Kavuri, V. C.Cochran, J. M.Xie, L.Busch, D. R.Katrasnik, J.Pathak, S.Chung, S. H.Lee, KijoonChoe, R.Czerniecki, B. J.Arridge, S. R.Yodh, A. G.
Issued Date
2016-07
Citation
Medical Physics, v.43, no.7, pp.4383 - 4395
Type
Article
Author Keywords
diffuse optical tomographyoptical mammographybreast cancer imagingCCD-based optical tomography instrumentation
Keywords
NEOADJUVANT CHEMOTHERAPYFLUORESCENCE CONTRASTHEALTHY BREASTTURBID MEDIAMAMMOGRAPHYWOMENSPECTROSCOPYABSORPTIONULTRASOUNDDENSITY
ISSN
0094-2405
Abstract
Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of sourcedetector pairs (106). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated. © 2016 American Association of Physicists in Medicine.
URI
http://hdl.handle.net/20.500.11750/5098
DOI
10.1118/1.4953830
Publisher
American Association of Physicists in Medicine
Related Researcher
  • 이기준 Lee, Kijoon
  • Research Interests Biomedical Optics; DOT; DSCA; NIRS; OCT; LSCI; Nonlinear Optics; Random Laser; Coherent Backscattering
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Department of Electrical Engineering and Computer Science Quantum & Biomedical Optics Lab 1. Journal Articles

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