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Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry
- Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry
- Ban, H. Y.; Schweiger, M.; Kavuri, V. C.; Cochran, J. M.; Xie, L.; Busch, D. R.; Katrasnik, J.; Pathak, S.; Chung, S. H.; Lee, K.; Choe, R.; Czerniecki, B. J.; Arridge, S. R.; Yodh, A. G.
- DGIST Authors
- Lee, K.
- Issue Date
- Medical Physics, 43(7), 4383-4395
- Article Type
- Aged; Anatomic Model; Breast Cancer; Breast Cancer Imaging; Breast Neoplasms; Breast Tumor; Cancer Patient; CCD-Based Optical Tomography Instrumentation; Chromatophore; Devices; Diagnostic Imaging; Diffuse Optical Tomography; Equipment Design; Female; Geometry; Human; Humans; Image Reconstruction; Imaging Phantom; Imaging, Three-Dimensional; Mammography; Models, Anatomic; Nuclear Magnetic Resonance Imaging; Optical Mammography; Optical Tomography; Phantoms, Imaging; Photon; Procedures; Three Dimensional Imaging; Tomography, Optical; Tumor Localization; Validation Study
- Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of sourcedetector pairs (106). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated. © 2016 American Association of Physicists in Medicine.
- AAPM - American Association of Physicists in Medicine
- Related Researcher
Biomedical Optics; DOT; DSCA; NIRS; OCT; LSCI; Nonlinear Optics; Random Laser; Coherent Backscattering
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