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Rootin, a compound that inhibits root development through modulating PIN-mediated auxin distribution

Title
Rootin, a compound that inhibits root development through modulating PIN-mediated auxin distribution
Authors
Jeong, SuyeongKim, Jun-YoungChoi, HyunmoKim, HyunminLee, IlhwanSoh, Moon-SooNam, Hong GilChang, Young-TaeLim, Pyung OkWoo, Hye Ryun
DGIST Authors
Nam, Hong GilLim, Pyung OkWoo, Hye Ryun
Issue Date
2015-04
Citation
Plant Science, 233, 116-126
Type
Article
Article Type
Article
Keywords
Abundance of Pin ProteinsArabidopsisArabidopsis ProteinArabidopsis ProteinsAuxin TransportersCarrier ProteinChemical GeneticsDrug EffectsGene Expression RegulationGene Expression Regulation, DevelopmentalGene Expression Regulation, PlantGeneticsGrowth, Development and AgingIndoleacetic Acid DerivativeIndoleacetic AcidsMembrane Transport ProteinsMetabolismPhytohormonePlant Growth RegulatorsPlant RootPlant RootsRoot DevelopmentSeedling
ISSN
0168-9452
Abstract
Plant roots anchor the plant to the soil and absorb water and nutrients for growth. Understanding the molecular mechanisms regulating root development is essential for improving plant survival and agricultural productivity. Extensive molecular genetic studies have provided important information on crucial components for the root development control over the last few decades. However, it is becoming difficult to identify new regulatory components in root development due to the functional redundancy and lethality of genes involved in root development. In this study, we performed a chemical genetic screen to identify novel synthetic compounds that regulate root development in Arabidopsis seedlings. The screen yielded a root growth inhibitor designated as 'rootin', which inhibited Arabidopsis root development by modulating cell division and elongation, but did not significantly affect shoot development. Transcript analysis of phytohormone marker genes revealed that rootin preferentially altered the expression of auxin-regulated genes. Furthermore, rootin reduced the accumulation of PIN1, PIN3, and PIN7 proteins, and affected the auxin distribution in roots, which consequently may lead to the observed defects in root development. Our results suggest that rootin could be utilized to unravel the mechanisms underlying root development and to investigate dynamic changes in PIN-mediated auxin distribution. © 2015 Elsevier Ireland Ltd.
URI
http://hdl.handle.net/20.500.11750/5196
DOI
10.1016/j.plantsci.2015.01.007
Publisher
Elsevier Ltd
Related Researcher
  • Author Lim, Pyung Ok CBRG(Complex Biology Research Group)
  • Research Interests Aging and programmen cell death in plants; RNA-based regulation of leaf aging; Synthetic genetics-based aging reprogramming
Files:
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Collection:
Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles


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