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A Capsule-Type Microrobot with Pick-and-Drop Motion for Targeted Drug and Cell Delivery

Title
A Capsule-Type Microrobot with Pick-and-Drop Motion for Targeted Drug and Cell Delivery
Authors
Lee, Seung MinKim, So YeunKim, Sang WonKim, Jin YoungMoon, Che IlNelson, Bradley J.Choi, Hong Soo
DGIST Authors
Kim, Jin YoungMoon, Che IlChoi, Hong Soo
Issue Date
2018-05
Citation
Advanced Healthcare Materials, 7(9), 1700985
Type
Article
Article Type
Article
Keywords
cell differentiationlaser lithographymagnetic manipulationmicrorobotstargeted cell transportation
ISSN
2192-2640
Abstract
A capsule-type microrobot exhibits pick-and-drop (P&D) motion to hold a particle within a confined volume and transports it via a corkscrewing motion. The P&D motion is possible because the capsule-type microrobot has two parts: a plunger and a cap. The fabricated microrobots are wirelessly controlled by a magnetic manipulator. Drugs or cells can be encapsulated in the container of the capsule-type microrobot by the P&D motion or attached to the surface of the cap, which can be used as a supporting structure. Therefore, the capsule-type microrobot can deliver suspended or adherent cells. The drug or cells are minimally exposed or not completely exposed to the surrounding fluid and do not experience shear force when encapsulated in the container. As a proof-of-concept, secure transportation of microparticles in the confined volume of the capsule via P&D motion is demonstrated. In addition, the cap is used as a scaffold for neuronal cell culture on a rat brain slice to demonstrate its biocompatibility and feasibility for targeted cell delivery. The proposed capsule-type microrobot is suitable for diverse applications, as it protects the encapsulated materials. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URI
http://hdl.handle.net/20.500.11750/5927
DOI
10.1002/adhm.201700985
Publisher
Wiley-VCH Verlag
Related Researcher
  • Author Moon, Cheil Moon Lab
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles
DGIST-ETH Microrobotics Research Center1. Journal Articles
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


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