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Role of hypothalamus in aging and its underlying cellular mechanisms

Role of hypothalamus in aging and its underlying cellular mechanisms
Kim, KeetaeChoe, Han Kyoung
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Kim, KeetaeChoe, Han Kyoung
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Aging is characterized by a progressive loss of several physiological functions that can cause various age-related disorders. Several factors have been identified as causes of aging to elucidate the decline in functions. Various aspects of physiological deterioration are controlled by the hypothalamus, a critical brain region that connects the neuroendocrine system to physiological functions. In addition, functional alterations in a set of agouti-related peptide/neuropeptide Y (AgRP/NPY) and pro-opiomelanocortin (POMC) neurons, a set of growth hormone-releasing hormone (GHRH) and somatostatin (SST) neurons, a set of arginine vasopressin (AVP) and vasoactive intestinal peptide (VIP) neurons, and a set of gonadotropin-releasing hormone (GnRH) and kisspeptin/neurokinin B/dynorphin (KNDy) neurons contribute to age-related physiological decline in energy metabolism, hormone regulation, circadian rhythm, and reproduction, respectively. The underlying cellular mechanism for the hypothalamus-mediated aging progression comprises dysregulation of nutrient sensing, altered intercellular communication, stem cell exhaustion, loss of proteostasis, and epigenetic alterations. Furthermore, mammalian target of rapamycin (mTOR), NF-kB, hypothalamic stem cell, autophagy, and SIRT1 have been recognized as critical factors or pathways mediating the mechanism. Perhaps, further dissection of these pathways or components could provide the potential for developing a therapeutic intervention for age-related diseases or the extension of healthy lifespan. © 2018 Elsevier B.V.
Elsevier Ireland Ltd
Related Researcher
  • 최한경 Choe, Han Kyoung 뇌과학과
  • Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
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Appears in Collections:
Department of Brain Sciences Laboratory of Animal Behavior and Circadian rhythm 1. Journal Articles
Department of New Biology CBRG(Complex Biology Research Group) 1. Journal Articles


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