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Comparative transcriptome analysis in Arabidopsis ein2/ore3 and ahk3/ore12 mutants during dark-induced leaf senescence

Comparative transcriptome analysis in Arabidopsis ein2/ore3 and ahk3/ore12 mutants during dark-induced leaf senescence
Kim, JeongsikPark, Su JinLee, Il HwanChu, HyosubPenfold, Christopher AKim, Jin HeeBuchanan-Wollaston, VickyNam, Hong GilWoo, Hye RyunLim, Pyung Ok
DGIST Authors
Kim, Jeongsik; Park, Su Jin; Lee, Il Hwan; Chu, Hyosub; Penfold, Christopher A; Kim, Jin Hee; Buchanan-Wollaston, Vicky; Nam, Hong GilWoo, Hye RyunLim, Pyung Ok
Issue Date
Journal of Experimental Botany, 69(12), 3023-3036
Article Type
Author Keywords
Leaf senescence involves degenerative but active biological processes that require balanced regulation of pro- and anti-senescing activities. Ethylene and cytokinin are major antagonistic regulatory hormones that control the timing and progression rate of leaf senescence. To identify the roles of these hormones in the regulation of leaf senescence in Arabidopsis, global gene expression profiles in detached leaves of the wild type, an ethylene-insensitive mutant (ein2/ore3), and a constitutive cytokinin response mutant (ahk3/ore12) were investigated during dark-induced leaf senescence. Comparative transcriptome analyses revealed that genes involved in oxidative or salt stress response were preferentially altered in the ein2/ore3 mutant, whereas genes involved in ribosome biogenesis were affected in the ahk3/ore12 mutant during dark-induced leaf senescence. Similar results were also obtained for developmental senescence. Through extensive molecular and physiological analyses in ein2/ore3 and ahk3/ore12 during dark-induced leaf senescence, together with responses when treated with cytokinin and ethylene inhibitor, we conclude that ethylene acts as a senescence-promoting factor via the transcriptional regulation of stress-related responses, whereas cytokinin acts as an anti-senescing agent by maintaining cellular activities and preserving the translational machinery. These findings provide new insights into how plants utilize two antagonistic hormones, ethylene and cytokinin, to regulate the molecular programming of leaf senescence. © The Author(s) 2018.
Oxford University Press
Related Researcher
  • Author Lim, Pyung Ok Plant Senescence Laboratory
  • Research Interests Aging and programmen cell death in plants; RNA-based regulation of leaf aging; Synthetic genetics-based aging reprogramming
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Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles
Department of New BiologyLab of Plant Molecular Communication1. Journal Articles
Department of New BiologyPlant Senescence Laboratory1. Journal Articles

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